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P504S与基底细胞标记物在前列腺病理诊断中的应用价值 被引量：3

Value of P504S and basal cell markers in the pathological diagnosis of prostatic specimen
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摘要 前列腺针吸活检是前列腺癌诊断中最重要的手段。由于前列腺针吸标本中常仅存有少量腺体,使外科病理学家在诊断上面临挑战。比较突出的问题是前列腺良性小腺泡增生(部分萎缩性腺体、拥挤腺体团等)和高级别前列腺上皮内瘤与高分化腺癌的鉴别。近年来国内外陆续发表了P504S及p63在辅助前列腺癌诊断的研究报告,其研究结论有相近亦有不同,现将这方面研究结果及存在的问题做一介绍。
作者 张杰 李小静
机构地区 复旦大学附属上海市第五人民医院病理科
出处 《诊断病理学杂志》 CSCD 2006年第5期389-391,共3页 Chinese Journal of Diagnostic Pathology
关键词 前列腺癌 P504S P63 CK34ΒE12
分类号 R711.3 [医药卫生—妇产科学]
  • 相关文献

参考文献21

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  • 2Kaufmann O,Fietze E,Mengs J,et al.Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas[J].Am J Clin Pathol,2001,116(6):823-830.
  • 3Genega EM,Hutchinson B,Reuter VE,et al.Immunophenotye of high-grade prostatic adenocarcinoma and urothelial carcinoma[J].Mod Pathol,2000,13(11):1186-1191.
  • 4Signoretti S,Waltregny D,Dilks J,et al.p63 is a prostate basal cell marker and is required for prostate development[J].Am J Pathol,2000,157(6):1769-1775.
  • 5Shah RB,Zhou M,Blanc M,et al.Comparison of the basal cellspecific markers,34βE12 and p63,in the diagnosis of prostate cancer[J].Am J Surg Pathol,2002,26(9):1161-1168.
  • 6Xu J,Stolk JA,Zhang X,et al.Identification of differentially expressed genes in human prostate cancer using subtraction and microarray[J].Cancer Res,2000,60:1677-1682.
  • 7Jiang Z,Woda BA,Rock KL,et al.P504S:a new molecular marker for the detection of prostate carcinoma[J].Am J Surg Pathol,2001,25(11):1397 -1404.
  • 8Luo J,Zha S,Gage WR,et al.Alpha-methylacyl-CoA racemase:a new molecular marker for prostate cancer[J].Cancer Res,2002,62(8):2220-2226.
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  • 10胡志红,程玲,吴萍,龚勇,黄征,郑美荣.CK34_βE12、p63和p504S联合检测在前列腺肿瘤鉴别诊断中的应用[J].诊断病理学杂志,2005,12(2):123-125. 被引量：20

二级参考文献24

  • 1姜众,马珂,吴群力,杨熙明.诊断前列腺癌的一种新的标记物——α-甲酰基辅酶A消旋酶[J].中华病理学杂志,2004,33(5):401-403. 被引量：11
  • 2孔祥田,邓方明,王静华,宓培,苏晋伟,夏同礼,郭应禄,顾方六.高分子量细胞角蛋白在前列腺腺癌鉴别诊断中的应用[J].中华病理学杂志,1996,25(4):199-201. 被引量：19
  • 3Xu J, Stolk JA, Zhang X, et al. Identification of differentially expressed genes in human prostate cancer using subtraction and microarry. Cancer Res, 2000,60: 1677-1682.
  • 4Jiang Z, Woda BA, Rock KL, et al. P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol, 2001, 25: 1397-1404.
  • 5Beach R, Gown AM, De Peralta-Venturina MN, et al. P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies. Am J Surg Pathol, 2002,26:1588-1596.
  • 6Magi-Galluzzi C, Luo J, Isaacs WB, et al. Alpha-methylacyl-CoA racemase: a variably sensitive immunohistochemical marker for the diagnosis of small prostate cancer foci on needle biopsy. Am J Surg Pathol, 2003,27:1128-1133.
  • 7Mostofi FK, Sesterhenn IA, Davis CJ, et al. Histological typing of prostate tumours. WHO, Geneva. Heidelberg: Springer, 2002.
  • 8Chen L, Jiang Z, Woda BA, et al. Decreased expression of alpha-methylacyl-CoA racemase/P504S in foamy gland carcinoma of the prostate. Mod Pathol, 2003, 16: 145A.
  • 9Zhou M, Jiang Z, Epstein JI. Expression and diagnostic utility of alpha-methylacyl-CoA racemase (P504S) in foamy gland and pseudohyperplastic prostate cancer. Am J Surg Pathol, 2003, 27:772-778.
  • 10Gupta N, De Peralta-Venturina MN, Gown A, et al. P504S antibody expression in putative precursor lesions of prostate carcinoma(PCa)-high grade prostatic intraepithelial neoplasia(HGPIN) and atypical adenomatous hyperplasia(AAH). Mod Pathol, 2003, 16:152A.

共引文献52

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诊断病理学杂志
2006年 第5期

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