摘要
目的探讨血清总胆固醇对全聋型突发性耳聋患者的预后影响,为临床治疗和预后评估提供依据。方法采用前瞻性队列研究设计方法,纳入2015年6月至2017年3月温州市中心医院确诊的全聋型突发性耳聋患者,收集其年龄、性别、高血压、糖尿病、眩晕、总胆固醇(TC)水平、甘油三酯(TG)水平、低密度脂蛋白(LDL-C)水平等资料。采用单因素和多因素Logistic回归方法分析TC水平对全聋型突发性耳聋预后的影响。结果 TC水平5.2 mmol/L^6.2 mmol/L时的患者治疗有效率高于TC水平<5.2 mmol/L的患者[单因素:RR=6.49,95%CI(3.16,13.30),P<0.001;多因素:RR=6.15,95%CI(2.66,14.3),P<0.001]。TC水平>6.2 mmol/L治疗有效率与TC水平<5.2 mmol/L的患者差异无统计学意义[单因素:RR=1.02,95%CI(0.52,2.00),P=0.960;多因素:RR=1.61,95%CI(0.55,4.73),P=0.386]。按性别进行亚组分析发现,无论男性和女性患者,TC水平5.2 mmol/L^6.2 mmol/L的治疗有效率均高于TC水平<5.2 mmol/L的患者,TC水平>6.2 mmol/L和TC水平<5.2 mmol/L的患者差异均无统计学意义(P值均>0.05)。结论本研究结果显示TC水平介于5.2 mmol/L^6.2 mmol/L时患者的预后最优。
Objectives To investigate the correlation between blood total cholesterol （TC） and prognosis of idiopathic sudden sensorineural hearing loss （ISSNHL） and to provide references for clinical treatment and prognosis assessment. Methods We included 232 ISSNHL patients with total deafness in Wenzhou Central Hospital from June 2015 to March 2017 using a prospective cohort design. Recording information including age, gender, hypertension, diabetes mellitus, vertigo, level of blood total cholesterol （TC）, level of triglyceride （TG）, level of low-density lipoprotein （LDL-C） and LDL/HDL ratio （LDL-C/HDL-C） were collected. Correlation between the prognosis of ISSNHL and blood total cholesterol were analyzed by univariabie and multivariable logistic regression analysis. Results The clinical effective rate of patients with TC ranging from 5.2 mmol/L to 6.2 mmol/L was higher than that of patients with TC lower than 5.2 mmol/L （univariable： RR=6.49, 95%CI 3.16 to 13.30, P〈0.001; multivariable-adjusted covariates： RR=6.15, 95%CI 2.66 to 14.3, P〈0.001） with significant difference. No significant difference was found between patients with TC lower than 5.2 mmol/L and patients with TC higher than 6.2 mmol/L （univariable： RR=l.02, 95%CI 0.52 to 2.00, P=0.960; multivariable-adjusted covariates： RR=1.61, 95%CI 0.55 to 4.73, P-0.386）. Gender-specific analysis showed for both male and female groups, the effective rates of patients with TC ranging from 5.2 mmol/L to 6.2 mmol/L were significantly higher than those of patients with TC lower than 5.2 mmol/L. There was no significant difference between patients with TC lower than 5.2 mmol/L and patients with TC higher than 6.2 mmol/L （P〉0.05） in either male group or female group. Conclusion The current study suggests that patients with levels of TC ranging from 5.2 mmol/L to 6.2 mmol/L predicts the best prognosis.
出处
《中国循证医学杂志》
CSCD
北大核心
2018年第1期8-12,共5页
Chinese Journal of Evidence-based Medicine
基金
国家自然科学基金(编号:81501933)
温州市科技局项目(编号:Y20170785)
关键词
全聋型突发性耳聋
血清总胆固醇
预后因素
前瞻性队列研究
Idiopathic sudden sensorineural hearing loss
Total cholesterol
Prognosis factor
Prospective cohort study
