摘要
目的通过分析老年晚期非小细胞肺癌患者的临床特征及治疗情况，探讨老年晚期非小细胞肺癌患者的治疗选择及影响预后的因素。方法对129例老年晚期非小细胞肺癌的性别、是否吸烟、组织学类型、临床分期、ECOG评分等临床特征、治疗方法及预后因素进行了回顾性分析及总结。结果老年晚期非小细胞肺癌平均总生存期（OS）20．85个月。化疗联合靶向治疗组总的客观缓解率（ORR）、无进展生存期（PFS）及0S均优于其他治疗组。单因素分析显示组织学类型、ECOG评分及治疗方法是影响OS的预后因素。多因素分析显示ECOG评分及治疗方法是OS的独立预后因素。结论ECOG评分及治疗方法是影响老年晚期非小细胞肺癌生存的独立预后因素。老年患者可以根据体力状况评分选择最佳治疗方法。
Objective To analyze of the clinical characteristics and treatment of elderly patients with advanced non - small - cell lung cancer （ NSCLC ） and to explore treatment choices and prognostic factors for these patients. Methods A total of 129 elderly patients with advanced NSCLC were enrolled. Clinical data were retrospectively analyzed in gen- der, smoking status, histological type, stage, Eastern Cooperative Oncology Group （ECOG） scores, treatment and prog- nostic factors. Results For elderly patients with advanced NSCLC, their mean survival time was 20.85 months. The chemotherapy combined with targeted therapy group showed improvements in the overall objective response rate （ORR） , progression -free survival （PFS） and overall survival （OS）, compared with other treatment groups. According to single analysis, histological type, ECOG scores and treatment were the prognostic factors influencing OS. The multivariate anal- ysis revealed that ECOG scores and treatment were independent prognostic factors influencing OS. Conclusion ECOG scores and treatment are the independent prognostic factors for OS in elderly patients with advanced NSCLC. Elderly pa- tients can choose the optimal treatment according to their conditions.
出处
《徐州医科大学学报》
CAS
2017年第12期794-798,共5页
Journal of Xuzhou Medical University
关键词
老年
非小细胞肺癌
临床特征
预后因素
elderly
non - small - cell lung cancer
clinical characteristics
prognostic factors
