摘要
目的:分析食管癌及其癌前病变人群的生活质量和影响因素,为提高该人群的生活质量提供依据。方法:采用癌症治疗功能评价食管癌特异量表(Functional Assessment of Cancererapy-Esophageal,FACT-E)对食管癌及癌前病变人群的生活质量进行测量,分析社会人口学、临床特征及治疗阶段等因素对患者生活质量的影响。结果:食管癌及其癌前病变人群生活质量标化FACT-E平均得分为(70.82±1.33)分,其中通用部分标化平均得分为(71.58±1.40)分,食管癌特异性部分标化平均得分为(69.62±1.54)分。肿瘤分期、治疗方案和治疗阶段对生活质量有显著影响(P值均<0.05)。随着肿瘤分期的进展,患者生活质量不断下降;对于不同的治疗方式,单独放疗的患者生活质量相对较高,手术联合化疗的患者生活质量优于单独手术治疗的患者(P值均<0.05);在不同治疗阶段中,主体治疗基本结束后的患者生活质量最差(P<0.05)。结论:实施早诊早治有利于改善食管癌及其癌前病变人群的生活质量,生活质量应纳入临床治疗方式的选择依据之一。
Objective： To investigate the situation and influential factors of quality of life （QoL） in patients with esophagus cancer and precancerosis, aimed at providing evidences for valid QoL promotion measures. Methods： QoLs of patients with esophagus cancer and precancerosis were measured by the Functional Assessment of Cancer Therapy- Esophageal （FACT-E）. The influences of social demography, clinical features and time point of treatment on QoL were analyzed. Results： The average score of standardized FACT-E was 70.82±1.33. The general part was 71.58±1.40 and the specific part was 69.62＋1.54. QoL was significantly influenced by clinical stage, type of therapy and time point of the treatment （all P 〈 0.05）. QoL became worse with the progression of the clinical stage. Patients treated with radiotherapy had relatively better QoL than other types of therapy （P 〈 0.05）. Compared with only surgery, a combination therapy of surgery and chemotherapy showed significantly higher QoL （P 〈 0.05）. The worst QoL was observed at the time point when the primary treatment was completed （P 〈 0.05）. Conclusion： Early diagnosis and treatment is regarded as an effective method to improve the QoL of patients with esophagus cancer and precancerosis. QoL is recommended to take into consideration during the therapy selection.
作者
程萱
丁晗玥
杨玉洁
邱五七
董佩
严晓玲
毛阿燕
CHENG Xuan;DING Hanyue;YANG Yujie;QIU Wuqi;DONG Pei;YAN Xiaoling;MAO Ayan
出处
《肿瘤》
CAS
CSCD
北大核心
2017年第12期1322-1328,共7页
Tumor
关键词
食管肿瘤
生活质量
影响因素分析
评价研究
Esophageal neoplasms
Quality of life
Root cause analysis
Evaluation studies
