摘要
目的研究妊娠期糖尿病患者(GDM)血清空腹血糖(FBG)、餐后2 h血糖(PBG)、糖化血红蛋白(Hb A1c)水平变化及其与不良妊娠结局的关系。方法选取妊娠期糖尿病患者120例设为观察组,选取同期未合并其他内科疾病正常产妇120例设为对照组,采用葡萄糖氧化酶法方法检测2组产妇FBG、PBG水平,采用糖化血红蛋白测定仪检测Hb A1c水平,对比2组不良妊娠结局及围产儿结局,分析FBG、PBG、Hb A1c水平与不良妊娠结局及围产儿结局相关性。结果观察组FBG、PBG、Hb A1c水平显著高于对照组(P<0.05);观察组肝内胆汁淤积症、胎儿窘迫、胎膜早破、早产、产后出血等不良妊娠结局发生率均显著高于对照组(P<0.05),且采用Spearman分析发现FBG、PBG、Hb A1c水平变化与肝内胆汁淤积症、胎儿窘迫、胎膜早破、早产、产后出血均具有显著正相关性(P<0.05),与羊水过少无相关性(P>0.05);观察组巨大儿、新生儿窒息、新生儿高胆红素血症、新生儿低血糖、新生儿肺炎发生率均高于对照组,Spearman分析发现FBG、PBG、Hb A1c水平变化与巨大儿、新生儿窒息、新生儿高胆红素血症、新生儿低血糖、新生儿肺炎均具有显著正相关性(P<0.05)。结论 GDM患者血清FBG、PBG、Hb A1c水平明显升高,且会导致多种不良妊娠结局的发生,是严重威胁母婴健康的重要因素之一。
Objective To study the changes of serum fasting blood glucose （FBG）, 2h postprandial blood glucose （PBG2h）, and HbAlc levels of gestational diabetes mellitus（GDM） and their relationship with adverse pregnancy outcomes. Methods A total of 120 GDM cases in our hospital were selected as observation group, and another 120 cases without maternal complications were selected as control group. The levels of FBG and PBG in the two groups were detected by glucose oxidase method, HbAlc levels were measured by glycosylated hemoglobin analyzer, adverse pregnancy outcomes and perinatal outcome were compared, the correlation between FBG, PBG, HbAlc levels and adverse pregnancy outcomes, perinatal outcomes were analyzed. Results The levels of FBG, PBG and HbA1 c in the observation group were significantly higher than that in the control group （P 〈 0. 05 ） ; Intrahepatic cholestasis, fetal distress, premature rupture of membranes, premature birth, postpartum hemorrhage and other adverse pregnancy outcomes of the observation group were higher than the control group, and the differences were statistically significant （ P 〈 0.05 ）. Spearman analysis showed that FBG, PBG and HbAlc were positively correlated with intrahepatic cholestasis, fetal distress, premature rupture of membranes, premature delivery and postpartum hemorrhage （ P 〈 0.05 ） , andhadnocorrelationwithamnioticfluid （ P 〉 0.05 ）. Giantchildren, neonatalasphyxia,neonatal hyperbilirubinemia , neonatal hypoglycemia and neonatal pneumonia of the observation group were higher than the control group. Spearman analysis showed that FBG, PBG and HbAlc were positively correlated with giant children, neonatal asphyxia, neonatal hyperbilirubinemia, neonatal hypoglycemia and neonatal pneumonia（P 〈 0.05 ）. Conclusion Serum FBG, PBG and HbAI c levels of GDM patients increase significantly, and it will lead to a variety of adverse pregnancy outcomes, so they were important factors that seriously threat maternal and child health.
出处
《实用临床医药杂志》
CAS
2017年第24期23-26,共4页
Journal of Clinical Medicine in Practice
关键词
妊娠期糖尿病
不良妊娠结局
糖化血红蛋白
空腹血糖
餐后2H血糖
gestational diabetes mellitus
adverse pregnancy outcomes
HbAlc
serum fasting blood glucose
2h postprandial blood glucose
