摘要
目的 探讨推拉动作后再高 G值暴露对大鼠记忆功能和行为的影响 .方法 2 4只雄性 SD大鼠随机分为对照组、+1 0 Gz/ 3min组和推拉组 3组 ,每组 8只 .记录 +Gz暴露后不同时间大鼠记忆功能和行为的变化 .结果 推拉组大鼠正确反应率在暴露后即刻与 2 d时较对照组显著降低 (P<0 .0 1 ) ,反应时在暴露后即刻、2 d及 4d时较对照组及 +1 0Gz/ 3 min组显著延长 (P<0 .0 1 ) ,错误数及错误时间在暴露后 6 h及 6 d时较对照组及 +1 0 Gz/ 3 min组显著增加 (P<0 .0 1 ) ,潜伏期在暴露后 6 h,2 d,4d及 6 d时较对照组及 +1 0 Gz/ 3 min组显著缩短 (P<0 .0 1 ) ,理毛次数在暴露后 6 h时与对照组相比显著减少 (P<0 .0 5) ,中央格内停留时间在暴露后即刻与对照组及 +1 0 Gz/ 3min组相比显著延长 (P<0 .0 1 ) ,平衡能力在暴露后即刻及 2 d时较对照组和 +1 0 Gz/ 3min组显著降低 (P<0 .0 1 ) .结论 推拉动作后再进行 +1 0Gz/
AIM To explore the effect of push pull maneuveron rat's memory and behavior. METHODS Twenty four male SD rats were randomly divided into three groups: the control group, the push pull and the +10 Gz/3 min groups. The changes in rat's memory and behavior were measured after +Gz exposure. RESULTS As compared with the control, rate of right reflex decreased significantly immediately and 2 days after push pull effect ( P <0.01); the number of make up decreased significantly 6 hours after the push pull effect ( P <0.05). As compared with the control and +10 Gz/3 min, time of reaction lengthened significantly at immediately, 2 days and 4 days after the push pull effect ( P < 0.01); the number of error and time of errors increased significantly 6 hours and 6 days after the push pull effect ( P < 0.01); latent time decreased significantly, 6 hours, 2 days, 4 days and 6 days after the push pull effect ( P <0.01); time stay in center grille lengthened significantly immediately after push pull effect ( P <0.01); balance function decreased significantly immediately and 2 days after the push pull effect ( P <0.01). CONCLUSION It is suggested that the exposure to +10 Gz for three minutes after 1 Gz exposure may induce a sustained disturbance in rat's memory and balance functions.
出处
《第四军医大学学报》
北大核心
2002年第16期1525-1529,共5页
Journal of the Fourth Military Medical University
基金
国家自然科学基金资助项目( 3980 0 158)
全军"十五"指令性课题 ( 0 1L 0 72 )
关键词
加速度
推拉动作
推拉效应
记忆
行为
大鼠
acceleration
push pull maneuver
push pull effect
memory
behavior
rats
