摘要
目的 比较自体角膜缘干细胞移植术与自体结膜移植术治疗翼状胬肉的临床疗效.方法 2015年1月至2016年4月初发性翼状胬肉68例（84眼）.患者随机分为：A组42眼行翼状胬肉切除联合自体角膜缘干细胞移植术,B组42眼行翼状胬肉切除联合自体结膜移植术.术后随访1年,比较两组患者角膜上皮愈合时间及复发率.结果 A组和B组的角膜上皮平均愈合时间分别为（2.87±0.64）d和（4.83±0.76）d,两组比较差异有统计学意义（t=3.480,P=0.009）;术后1年A组复发2眼（4.8%）,B组复发5眼（11.9%）,两组比较差异有统计学意义（χ2=4.368,P=0.036）.结论 自体角膜缘干细胞移植术比较自体结膜移植术角膜上皮愈合得更快,复发率更低.
Objective To compare the clinical efficacy of transplantation of autologous corneal limbal stem cell and autologous conjunctiva transplantation in the treatment of pterygium .Methods The data of 84 eyes of 68 cases with primary pterygium from Jan .2015 to Apr.2016 were collected .The patients were randomly divided into two groups .Group A, 42 eyes, received pterygium excision combined with autologous limbal stem cell transplantation .Group B, 42 eyes, received pterygium excision combined with autologous conjunctiva transplantation .The follow-up time was 1 year.Corneal epithelial healing time and the recurrence of pterygium were compared between the two groups .Results The time of corneal epithelial healing was （2.87 ±0.64） days in group A and （4.83 ±0.76） days in group B,the difference was statistically significant between the two groups （t=3.480,P=0.009）.Two eyes relapsed in group A, the recurrence rate was 4.8%;8 eyes relapsed in group B, the recurrence rate was 11.9%.The differences between two groups were statistically significant （χ2 =4.368, P=0.036）.Conclusion Autologous corneal limbal stem cell transplantation can accelerates corneal wound recovery ,reduces the recurrence of pterygium .
作者
宋玉艳
谢铃
刘素芝
周卫英
Song Yuyan;Xie Ling;Liu Suzhi;Zhou Weiying(Department of Ophthalmology, Occupational Disease Hospital of Xinjiang Uygur Autonomous Region, Wulumuqi 830091, China)
出处
《中华眼外伤职业眼病杂志》
2017年第12期940-942,共3页
Chinese Journal of Ocular Trauma and Occupational Eye Disease
关键词
翼状胬肉
自体角膜缘干细胞移植术
自体结膜移植术
Pterygium
Transplantation, autologous limbal stem cell
Transplantation, autologous conjunctiva
