摘要
心肌梗死后心肌纤维化是心脏重塑从而导致心脏衰竭的重要原因,造成心肌梗死后心室重构的机制复杂,是多因素相互作用、共同参与的结果。但其中机制较为明确,并且在心肌纤维化进程中扮演重要作用的是TGF-β1依赖的Smads信号通路。心肌梗死后,活化的TGF-β1可以通过下游Smads信号发挥持续的生物学效应,活化成纤维细胞,引起细胞外基质沉积,使心肌成纤维细胞向肌成纤维细胞分化。因此,如何阻抑或控制TGF-β1/Smads信号通路是治疗心肌梗死后心肌纤维化的重要研究方向,该文就当前基于TGF-β1/Smads信号通路治疗心肌梗死后心肌纤维化的研究进行综述。
Myocardial fibrosis leads to cardiac remodeling and heart failure after myocardial infarction. The mechanism of ventricular remodeling after myocardial infarction is complicated,which results from multi-factor interactions. TGF-β1-dependent Smads signal pathway is a definite mechanism which plays an important role in the process of myocardial fibrosis. Myocardial infarction activates the TGF-β1,which links the downstream Smads signaling to play a sustained biological effects via the accumulation of activated cardiac fibroblasts and excess deposition of extracellular matrix,and the differentiation from myocardial fibroblasts to myofibroblasts. Therefore,how to block or control TGF-β1/Smads signaling pathway is an important research direction for the treatment of myocardial fibrosis after myocardial infarction. This paper reviews the current studies of the treatment of myocardial fibrosis after myocardial infarction based on the TGF-β1/Smads signaling pathway.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2018年第1期5-8,共4页
Chinese Pharmacological Bulletin
基金
国家中医临床研究基地业务建设科研专项课题(No JDZX2015006)
