摘要
目的观察益肾活血中药+电针穴位刺激治疗脑梗死后记忆功能障碍疗效及对脑电位、氧化应激指标的影响。方法将120例脑梗死后记忆功能障碍患者随机分为2组,对照组60例给予西药多奈哌齐治疗,观察组60例在此基础上加用益肾活血中药+电针穴位刺激治疗,2组治疗时间均为4周。观察2组治疗前后中医证候积分、SDSVD评分、MoCA评分、MMSE评分、ADL量表评分、P300潜伏期、P300波幅、丙二醛(MDA)及超氧化物歧化酶(SOD)水平变化情况,统计2组近期疗效。结果 2组治疗后记忆力减退、表情呆滞、眩晕耳鸣、疲倦乏力、舌红苔黄腻及脉滑数积分均显著降低(P均<0.05),且观察组治疗后各项积分均显著低于对照组(P均<0.05);2组治疗后SDSVD评分、ADL量表评分及P300潜伏期均显著降低(P均<0.05),MoCA评分、MMSE评分及P300波幅均显著提高(P均<0.05),且观察组治疗后各项指标改善情况均显著优于对照组(P均<0.05);观察组近期治疗总有效率显著高于对照组(P<0.05)。结论益肾活血中药+电针穴位刺激治疗脑梗死后记忆功能障碍可有效缓解临床症状体征,促进记忆功能恢复,改善日常生活质量,并有助于调节脑电位和氧化应激指标水平。
Objective It is to observe the effect of drug for tonifying kidney and activating blood plus electric-acupunc- ture point stimulation on memory dysfunction after cerebral infarction and its effect on brain potential and oxidative stress in- dex. Methods 120 patients with memory dysfunction after cerebral infarction were randomly divided into 2 groups, the con- trol group （n = 60） was treated with western medicine Donepezil, the observation group （n = 60） was treated with the drug for tonifying kidney and activating blood plus electric-acupuncture point stimulation on the basis of treatment in the control group. Both groups were treated for 4 weeks. The changes of scores of traditional Chinese medical syndrome, SDSVD, Mo- CA, MMSE, ADL, P300 latency period, P300 amplitude and the levels of malondialdehyde （MDA） and superoxide dis- mutase （SOD） before and after treatment were observed, the recent curative effects were evaluated in both groups. Results After treatment, the scores of poor memory, dull expression, dizziness, tinnitus, fatigue, red tongue and yellow coated tongue and rapid and slippery pulses were significantly decreased （ P 〈 0.05） , and the scores in the observation group were significantly lower than those in the control group （P 〈 0.05）. After treatment, the scores of SDSVD, ADL and P300 la- tency period were lower or shorter, while the scores of MoCA, MMSE and P300 amplitude were higher or more than those before treatment in both groups（P 〈 0.05）, and the improvements in the observation group were better than those in the control group （P 〈 0.05 ）. The total effective rate of treat^aent group was significantly higher in the observation group than that in the control group （ P 〈 0.05 ）. Conclusion The drug for tonifying kidney and activating blood plus electric-acupunc- ture point stimulation can effectively relieve the clinical symptoms and signs, promote the recovery of memory function, im- prove the quality of daily life, and is helpful for the regulation of brain potential and oxidative stress indexes in the treatment of memory dysfunction after cerebral infarction.
出处
《现代中西医结合杂志》
CAS
2018年第1期39-42,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
中医药
脑梗死
记忆功能障碍
脑电位
氧化应激指标
traditional Chinese medicine
cerebral infarction
memory dysfunction
brain potential
oxidative stress index
