摘要
目的 :安络化纤丸联合恩替卡韦对慢性乙型肝炎病毒(HBV)感染者病毒复制及肝纤维化指标、Th1/Th2细胞因子的影响。方法 :207例纳入研究的慢性HBV感染病例随机分为观察组(107例)和对照组(100例),两组依据病理类型再分为慢性乙型肝炎(CHB)、乙肝肝硬化两个亚组。对照组在常规治疗的基础上给予恩替卡韦,观察组在对照组的基础上给予安络化纤丸。治疗3个月,观察两组乙肝病毒脱氧核糖核酸(HBV-DNA)载量及肝纤维化指标[透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原肽(PⅢP)]、Th1/Th2细胞因子[白介素-2(IL-2)、白介素-10(IL-10)、白介素-4(IL-4)及干扰素-γ(IFN-γ)]水平。结果 :(1)治疗后,两组各亚组HBV-DNA拷贝数的绝对数均明显下降(P<0.05),且观察组各亚组的下降幅度均大于对照组的同名亚组(P<0.05);(2)治疗后,两组各亚组的LN、HA、Ⅳ-C、PⅢP均明显下降(P<0.05),且观察组各亚组LN、HA、Ⅳ-C、PⅢP的下降幅度大于对照组的同名亚组(P<0.05);(3)治疗后,两组各亚组的IL-2、IFN-γ明显上升而IL-4、IL-10明显下降(P<0.05),且观察组各亚组IL-2、IFN-γ、IL-4、IL-10的变化幅度均大于对照组同名亚组(P<0.05)。结论:安络化纤丸联合恩替卡韦用于慢性HBV感染能更有效的抑制乙肝病毒复制,且抑制肝纤维化及调节免疫的作用更显著,优于单用恩替卡韦。
Objective ：To observe the effect of Anluo Huaxian Pill combined with entecavir on viral replication,liver fibrosis markers and Th1/Th2 cytokines in patients with chronic hepatitis B virus（HBV）infection.Methods ：207 cases of patient with chronic HBV infection were divided into the observation group（107 cases）and the control group（100 cases）,and the two groups were divided into two subgroups according to pathological types ：chronic hepatitis B（CHB）and hepatitis B cirrhosis.The control group was given entecavir based on conventional therapy,and the observation group was given Anluo Huaxian Pill based on the control group.For 3 months,to observe the differences of hepatitis B virus deoxyribonucleic acid（HBV-DNA） load and liver fibrosis indexes [hyaluronic acid（HA）,laminin（LN）,collagen type IV（IV-C）,type III procollagen（PⅢP）],Th1/Th2 [interleukin-2（IL-2）,interleukin-10（IL-10）,interleukin-4（IL-4）and interferon gamma-γ（IFN-γ）] between the two groups.Results ：（1）After treatment,The absolute number of HBV-DNA copies in each subgroup of the two groups decreased significantly（P〈0.05）,and the decrease rate of each subgroup in the observation group was greater than that in the control group（P〈0.05）;（2）After treatment,The two group of LN,HA,IV-C,P III P were significantly decreased（P〈0.05）,and the observation group of LN,HA,IV-C,P III P decreased than that of control group of the same name subgroup（P〈0.05）;（3）After treatment,two group of IL-2 IFN-γwere creased and IL-4,IL-10 were decreased（P〈0.05）,and the changes of IL-2,IFN-γ,IL-4,IL-10 in each subgroup of the observation group were higher than those in the control group（P〈0.05）.Conclusion ：Anluo Huaxian Pill combined with entecavir have more effectively inhibit hepatitis B virus replication,and more remarkable on inhibit the liver fibrosis and regulating the immune function,which is more significant than that of entecavir alone.
出处
《辽宁中医药大学学报》
CAS
2017年第12期130-133,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
秦皇岛市科学技术研究与发展计划自筹经费项目(201602A198)
