摘要
目的分析血管内皮生长因子(VEGF)对于急性白血病预后的预测作用。方法选取该院确诊的急性白血病患者73例及对照组80例,白血病组患者留取血清及髂后上棘穿刺活检取骨髓组织;对照组受试对象留取血清进行检测和比较。用免疫组化的方法检测VEGF表达水平。结果血清和骨髓VEGF表达阳性与阴性的急性白血病患者治疗后1年随访,血清VEGF表达阳性患者中急性髓性白血病复发病例19例(57.58%),阴性患者中复发1例(20.00%),阳性患者中复发比例高于阴性患者,比较差异有统计学意义(P<0.05);血清VEGF表达阳性患者中检出急性淋巴细胞白血病复发病例16例(51.62%);骨髓VEGF表达阳性患者中急性髓性白血病复发病例和急性淋巴细胞细胞白血病复发病例各17例(48.57%)。治疗后1年随访测定血清和骨髓VEGF水平,提示两型急性白血病复发者的血清和骨髓VEGF水平均高于缓解者,差异有统计学意义(P<0.05)。结论血中以及骨髓中的VEGF水平均可在急性白血病的初治以及复发状态下高表达,而在缓解状态下表达显著下降,特别是在复发状态下,表达水平相对更高,提示了血与骨髓中VEGF表达增高可以协助预测复发风险。
Objective To analyze the prognostic value of vascular endothelial growth factor in acute leukemia. Methods 73 patients with acute leukemia as the leukemia group and 80 patients as the control group were selected. The serum and bone marrow tissue taken by puncture biopsy of posterior superior iliac spine of the leukemia group were collected The serum of the control group was collected and compared. The expression of vascular endothelial growth factor was detected by immunohistochemistry. Results The acute leukemia patients with positive and negative serum VEGF or with positive and negative bone marrow VEGF were followed. The positive expression of serum VEGF was found in 19 recurrent cases of acute myeloid leukemia （57. 58%） and the nega-tive expression of serum VEGF was found in 1 recurrent cases （20. 00%）. The recurrence rate in patients with positive serum VEGF was higher than that in patients with negative serum VEGF,and the difference was statistically significant （P〈0. 05） ; the positive expression of serum VEGF was found in 16 recurrent cases of acute lymphoblastic leukemia （51. 62%） ;the positive expres-sion of bone marrow VEGF was found in 17 recurrent cases of acute myeloid leukemia and 17 recurrent cases of acute lymphoblastic leukemia respectively （48. 57%）. The serum VEGF level and the bone marrow VEGF were measured on follow-up one year after treatment, which showed the levels of recurrent cases of acute myeloid leukemia and acute lymphoblastic leukemia were all higher than those of Remission patients and the difference was statistically significant（P〈0. 01）. Conclusion The levels of VEGF in blood and bone marrow cells can be highly expressed in the initial treatment and recurrence of acute leukemia, especially in the relapsed condition,the expression level is higher, but the expression level is significantly decreased in the remission state. Increased expression of VEGF in blood and bone marrow cells may help to predict an increased risk of recurrence.
出处
《国际检验医学杂志》
CAS
2017年第23期3288-3290,共3页
International Journal of Laboratory Medicine
关键词
血管内皮生长因子
急性白血病
复发
预测
vascular endothelial growth factor
acute leukemia
recurrence
prediction
