摘要
本研究旨在探讨骨桥蛋白(osteopontin,OPN)和血管内皮生长因子(VEGF)在急性白血病中的表达及其与急性白血病(AL)血管新生的关系。应用酶联免疫吸附试验(ELISA)测定25例初发未治、19例完全缓解、14例未缓解、11例复发的AL患者血清中OPN和VEGF的蛋白含量,并与正常对照组比较。结果表明,AL初发未治组、未缓解组、复发组患者血清OPN和VEGF的含量均明显高于正常对照组和缓解组(p<0.01);缓解组患者血清OPN和VEGF的含量与正常对照组比较,差异均无统计学意义(p>0.05)。OPN和VEGF与AL发生、发展呈正相关。结论:OPN和VEGF与AL的发生、发展密切相关,OPN可能通过上调VEGF促进血管生成,因而阻抗OPN有望成为白血病治疗的新靶点。
The aim of this study was to investigate the expression of osteopontin （OPN） and vascular endothelial growth factor （VEGF） in acute leukemia （AL） and its significance in the angiogenesis and progress of AL. Serum levels of OPN and VEGF in 25 de novo patients, 19 complete remitted （CR） patients, 14 uuremitted patients, and 11 relapsed patients with AL were measured by enzyme-linked immunosorbent assay （ELISA）, and compared with those in normal controls. The results showed that the serum levels of OPN and VEGF in de novo, unremitted, relapsed patients were significantly higher than those in normal controls and CR patients （p 〈0.01 ） . Compared with de novo AL patients group, the serum levels of OPN and VEGF in CR patients decreased significantly, but showed no significant difference from those in normal controls （p 〉 0.05 ）. The expression of OPN and VEGF in acute leukemia was positively correlated with occurence and development of AL. It is concluded that the expressions of OPN and VEGF are closely related with AL occurence and development, the OPN may regulate VEGF expression and promote angiogeness in acute leukemia. Preventing expressions of OPN may seem as targets for leukemia therapy in the future.
出处
《中国实验血液学杂志》
CAS
CSCD
2011年第4期926-929,共4页
Journal of Experimental Hematology
基金
河南省卫生厅科技攻关项目
编号201003081
