摘要
目的分析常州地区女性生殖道人乳头瘤病毒(HPV)感染状况以及分布特点,为女性宫颈癌的防治及HPV疫苗研制提供流行病学依据。方法收集2014年1月至2016年6月常州市中医医院、常州市妇幼保健院、常州市第二人民医院和常州武进医院的女性宫颈脱落细胞样本共32 215份,检测HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、82共17种高危亚型和HPV6、11、42、43、81、83共6种低危亚型。按年龄将研究对象分为6组:<20岁组、>21~30岁组、>31~40岁组、>41~50岁组、>51~60岁和>61岁组,并对HPV感染病例的年龄分布及基因型进行分析。结果共检测样本32 215例,检出HPV阳性样本8 396例,HPV阳性检出率为26.06%。HPV高危亚型按检出频次由高到低依次为16(4.55%)、52(4.43%)、58(2.75%)、53(2.42%)、51(2.16%)、68(1.85%)、56(1.73%)、33(1.40%)、18(1.38%)、66(1.33%)、59(1.26%)、39(1.08%)、31(1.02%)、35(0.89%)、45(0.42%)、73(0.26%)和82(0.15%)。HPV低危亚型由高到低依次为81(2.96%)、43(1.86%)、42(1.62%)、6(1.27%)、11(0.80%)和83(0.26%)。结论常州地区女性生殖道HPV感染的主要亚型为高危亚型HPV16、52。
Objective To observe the human papillomavirus （HPV） prevalence and its distribution character among females inChangzhou and to provide epidemiological data for the prevention of cervical cancer and development of HPV vaccine. Methods The clinical material consisted of 32 215 women, who were from Changzhou Hospital T. C. M, Changzhou Maternal and ChildHealth Care,The Second Peopled Hospital of Changzhou and Changzhou Wujin Hospital from January 2014 to June 2016. 17 kindsof high-risk subtypes （ HP VI6 , 18, 31, 33, 35, 39, , 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82） and 6 kinds of low-risk subtypes（HP V6, 11 , 42,43,81, 83） were detected. All cases were divided into six groups according to the age （〈20 ;〉21 to 30;31 to 40;41to 50;51 to 60;and〉61） and the age distribution of women infected with HPV and genotypes of HPV were analyzed. Results Outof 32215 cervical cell specimens,8396 cases were detected HPV infections with the position rate of 26. 06%. In seventeen types ofhigh-risk HPV, HPV 16 （4. 55%） were the most common subtype, followed by 52 （4. 43%）,58 （2. 75%）,53 （2. 42%）,51（2.16%）,68 （1.85%）,56 （1.73%）,33 （1.40%）,18 （1.38%）,66 （ 1.33%）,59 （1.26%）,39 （1.08%）,31 （1.02%）,35（0.89%）,45 （0. 42%）,73 （0. 26%）, and 82 （0. 15% ）. Six types of low-risk HPV were detected, of which HPV 81 （2. 96%） wasthe most common subtypes？followed by 43 （1.86%）？42 （1. 62%）,6 （1. 27%）,11 （0. 80%） and 83 （0. 26%）. Conclusion Thepredominant genotypes of HPV 16 and, 52 infection in female reproductive tract are the highest.
出处
《国际检验医学杂志》
CAS
2017年第23期3280-3282,共3页
International Journal of Laboratory Medicine
基金
常州市科技计划项目(CJ20159047)
