摘要
微针是一种实现无痛和微创的给药新技术。其原理是穿刺皮肤产生微米级的给药通道,以增强皮肤对大分子药物的渗透性。生物可降解微针主要解决不可降解材料微针断裂于皮肤内造成的安全问题。本文对生物可降解微针的特点、可降解材料及其最新研究进展进行阐述,并分析其发展现状和趋势。
Microneedle is a painless and minimally invasive transdermal drug delivery. It can enhance the permeability of skin for macromolecular drugs by puncturing and creating a micron-level drug delivery channel in the skin. The biodegradable microneedles aim to solve the problem that nondegradable-material microneedles may break under skin and cause adverse reaction. This article provides an overview of the characteristics of biodegradable microneedles,the biodegradable materials used,its recent research progress,the development status and the tendency.
出处
《国际药学研究杂志》
CSCD
北大核心
2017年第8期778-782,共5页
Journal of International Pharmaceutical Research
基金
广州市重点实验室专项资助项目(2014SY000005)
关键词
微针
生物可降解材料
经皮给药
microneedle
biodegradable material
transdermal drug delivery
