摘要
研究杜仲茶对便秘模型小鼠的通便效果。将昆明种小鼠随机分为溶剂对照组、模型组、阳性对照组和三个剂量的给药组,雌雄各半。溶剂对照组和模型组给予20 m L/kg BW的蒸馏水;阳性对照组给予1.0 g/kg BW的麻仁丸;给药组分别经口给予低、中、高剂量(0.4、0.8、1.6 g/kg BW)的杜仲茶提取液。连续灌胃8 d后,记录各组小鼠的体重,首次排黑便时间、5 h内排便粒数,测定粪便重量、含水量和小肠墨汁推进率,并采用SPSS软件对数据进行显著性分析。结果表明,实验剂量杜仲茶提取液对小鼠生长无明显影响(p>0.05),低、中、高剂量杜仲茶提取液对首次排黑便时间、5 h内排便粒数、粪便重量、含水量和小肠墨汁推进率的影响依次为不显著(p>0.05)、显著(p<0.05)及极显著(p<0.01)。杜仲茶对小鼠具有通便的作用。
Objective：To study the effect of Eucommia tea on defecating function in constipated mice. Methods：Kunming mice were randomized into 6 groups：solvent group, model group, positive group and 3 dosages groups. Mice of solvent group and model group were given by gavage with distilled water of 20 mL/kg BW once a day for 8 days, mice of positive group were given by gavage with Maren Wan of 1.0 g/kg BW once a day for 8 days, mice of 3 dosages group were given by gavage with different dosages of Eucommia tea（0.4,0.8,1.6 g/kg BW） once a day for 8 days.Then the weight of each group of mice was recorded ,the time of the first black feces to be excreted and the number of feces within 5 hours were observed, water content of mice feces and ink propelling rates were mensurated, statistical analysis was performed using the SPSS software. Results：There was no obvious effect about experimental dosages of Eucommia tea extrat on Body weight of mice, and the effects of lower, medium and higher dosages of Eucommia tea extrat on the time of the first black feces to be excreted, the number of feces within 5 hours, water content of mice feces and ink propelling rates respectively were no significant （p 〉 0.05 ） , significant （p 〈 0.05 ）and very significant （p 〈 0.01 ）.Conclution：The results demonstrate that Eucommia tea has significantly cathartic effects in mice.
出处
《食品工业科技》
CAS
CSCD
北大核心
2017年第23期280-283,共4页
Science and Technology of Food Industry
基金
"十二五"国家科技支撑计划资助(2012BAD21B05)
关键词
杜仲茶
便秘小鼠
润肠通便
Eucommia tea
constipated mice
cathartic effects
