摘要
目的:研究艾滋病合并乙型肝炎后肝硬化患者血清生化指标及T淋巴细胞亚群水平变化的临床价值。方法:选取2010年5月2016年4月我院收治的艾滋病合并乙型肝炎后肝硬化患者89例为研究组,以同期确诊的150例单纯乙肝肝硬化患者为对照组,均进行对症治疗,比较其肝癌发病率、治疗前后血清病毒载量、γ谷氨酰转移酶(γ-GT)活性及T淋巴细胞亚群(CD3^+、CD4^+、CD8^+)水平。结果:治疗前研究组病毒载量、γ-GT活性高于对照组(P<0.05),CD3^+、CD4^+、CD8^+水平低于对照组(P<0.05);治疗后研究组病毒载量(24.29±1.03)拷贝/mL、γ-GT(56.29±1.28)U/L活性较对照组降低(P<0.05),而其CD3^+(1345.21±6.97)个/μL、CD4^+(286.19±1.97)个/μL、CD8^+(870.65±1.59)个/μL水平较对照组明显升高(P<0.05);观察组肝癌发病率16.85%明显高于对照组5.33%(P<0.05)。结论:艾滋病合并乙型肝炎后肝硬化患者肝癌发病率高于单纯乙肝肝硬化,且其血清生化指标及T淋巴细胞亚群水平在治疗前后发生明显变化,临床应加以监测。
Objective： To investigate the clinical value of the level change of serum biochemical markers and T lymphocyte subsets in patients with liver cirrhosis after having acquired immune deficiency syndrome （AIDS） and hepatitis B. Methods： Eighty-nine patients with fiver cirrhosis after having AIDS and hepatitis B, who were hospitalized in our hospital between May 2010 and April 2016, were included as the study group in the study. A contemporary cohort of 150 patients diagnosed with simple hepatitis B cirrhosis was included as the control group. Both groups received symptomatic treatment. The incidence of liver cancer, and serum viral load,γ glutamyltransferase （γ-GT） activity and levels of T lymphocyte subsets （CD3＋, CD4＋, CD8＋） before and after treatment were compared between the two groups. Results： The viral load and γ-GT activity in the study group were higher than those before the control group （P〈0.05） , whereas the levels of CD3＋, CD4＋ and CD8＋ were lower than those in the control group （P〈0.05）. The viral load [ （24.29± 1.03） copy/mL and 7-GT activity [ （56.29± 1.28） U/L] in the study group were decreased compared with those in the control group after the treatment （ P〈 0.05 ）, whereas the levels of CD3 ＋ [ （ 1 345.21 ±6.97） u/μL ], CD4＋ [ （ 286.19 ± 1.97 ） u/μL ] and CD8＋[ （870.65± 1.59） u/μL] were significantly increased compared with those in the control group （P〈 0. 05 ）. The incidence of fiver cancer in the study group was significantly higher than that in the control group （ 16.85% vs 5.33%, P〈0.05）. Conclusion： The incidence of fiver cancer in patients with liver cirrhosis after having AIDS and hepatitis B is higher than that in patients with simple hepatitis B cirrhosis, and the serum biochemical indexes and T lymphocyte subsets show significant changes before and after treatment, which should be monitored clinically.
出处
《广州医科大学学报》
2017年第2期36-38,共3页
Academic Journal of Guangzhou Medical University
