摘要
目的探讨地中海贫血基因检测技术在厦门地区不孕不育患者中的运用价值。方法对2015年4月~2017年5月来我院生殖中心就诊的患者1896例进行血常规、地中海贫血基因及血红蛋白电泳,并对结果进行分析。结果厦门地区地区不孕不育患者地中海贫血检出率为12.89%,α-地中海贫血143例,β-地中海贫血109例,α-地中海贫血合并β-地中海贫血4例,其中SEA杂合缺失的α地中海贫血检出最多,占到地中海贫血的59.38%;血常规正常患者地中海贫血检出率远远低于异常患者(P<0.05)。结论地中海贫血基因检测技术是不孕不育人群地贫检出的有效手段,可以联合MCV、MCHC、血红蛋白电泳进行地贫的诊断,杜绝重症型地贫和减少地贫携带者患儿的出生。
Objective：To investigate the value of thalassemia gene detection in infertile patients in Xiamen area. Method：The blood routine,thalassemia gene and hemoglobin electrophoresis were performed in 1896 patients from our reproductive center in our hospital from April 2015 to May 2017,and the results were analyzed. Result：Infertility patients in Xiamen area of Mediterranean anemia detection rate was 12.89%,143 cases of α-thalassemia,beta thalassemia in 109 cases,4 cases ofα-thalassemia with beta thalassemia,which SEA heterozygous deletion of alpha thalassemia was the most,accounted for 59.38% of patients with thalassemia;normal blood routine detection of thalassemia the rate is lower than that of patients with abnormal round（P〈0.05）. Conclusion：Thalassemia gene detection technology is the effective means of detection of thalassemia in infertile patients,the diagnosis can be combined with MCV,MCHC,hemoglobin electrophoresis of thalassemia,to prevent severe thalassemia and reduce the birth of children with thalassemia carriers.
出处
《中国优生与遗传杂志》
2017年第11期35-36,60,共3页
Chinese Journal of Birth Health & Heredity
基金
厦门市科技计划项目3502Z20144036
