摘要
目的:探讨阿立哌唑配伍选择性单胺能拮抗剂利培酮治疗对精神分裂症患者血清髓鞘碱性蛋白(MBP)、胶质源性神经营养因子(GDNF)水平的影响。方法:选取2015年6月至2016年6月在我院接受治疗的100例精神分裂症患者,按照随机数字表法分为对照组和研究组各50例。对照组服用利培酮治疗,研究组在对照组基础上服用阿立哌唑。比较两组患者的疗效、认知功能以及血清MBP、GDNF水平。结果:治疗后,两组患者的阳性和阴性症状量表(PANSS)评分均显著降低(P<0.05),且研究组下降幅度较大,两组差异有统计学意义(P<0.05),治疗后两组的认知评分也有明显变化(P<0.05),而治疗组变化幅度更大;研究组治疗后血清MBP水平较治疗前及对照组均有显著下降(均P<0.05),两组患者治疗后的GDNF水平均显著升高,研究组升高幅度显著大于对照组(P<0.05)。结论:阿立哌唑联合利培酮能显著改善精神分裂症患者的精神症状,减轻受损的认知功能,降低MBP水平,提高GDNF水平,为精神分裂症的治疗提供新思路。
Objective： To investigate the effect of aripiprazole combined with selective monoaminergic antagonist risperidone on serum myelin basic protein （MBP） and gGlial cellline- derivedneurotrophic factor （GDNF） in the treatment of schizophrenia patients. Methods： One hundred schizophrenia patients admitted to our hospital from Jun. 2015 to Jun. 2016 were randomly divided into control group and study group with 50 cases in each group. The control group was treated with risperidone, while the study group was treated with aripiprazole in addition to risperidone. The efficacy, cognitive function and serum MBP, GDNF levels were compared between the two groups. Results： After treatment, positive and negative syndrome scale （PANSS） scores of the two groups were both significantly decreased （P 〈 0.05 ）, but the scores in study group decreased more than those in control group with statisticl difference and cognitive scores of the two groups also changed significantly（ P 〈 0.05 ）. MBP levels in the study group were lower than those before treatment and those in the control group （ P 〈 0.05 ）. After the treatment, the levels of GDNF were increased in the two groups, and the levels in the study group were much higher than those in the control group （ P 〈 0.05 ）. Conclusion： Aripiprazole combined with risperidone can significantly improve psychiatric symptoms in patients with schizophrenia, reduce cognitive impairment, decrease the level of MBP and increase the level of GDNF. It can provide new ideas for the treatment of schizophrenia.
出处
《现代医学》
2017年第10期1430-1434,共5页
Modern Medical Journal
