摘要
目的探讨精神分裂症患者认知功能受损和阴性症状之间的关系。方法选取2011年2月—2014年7月在北京大学第六医院门诊及住院治疗的服用单一抗精神病药物的精神分裂症患者108例为病例组。同期采用方便抽样法选取本市社区的100例健康志愿者为正常对照组。基线时分别采用数字符号转换测验、动物流畅性测验、韦氏记忆量表修订版(甲式)评定病例组和正常对照组信息处理速度、词语流畅性和记忆能力(认知功能),采用阳性与阴性症状量表(PANSS)评定病例组患者精神症状。6周后再次评定42例仍服用单一抗精神病药物的精神分裂症患者的认知功能和精神症状。结果病例组患者信息处理速度评分、词语流畅性评分、记忆能力评分均低于正常对照组(P<0.05)。基线时患者精神症状各项评分及PANSS总分与6周后比较,差异有统计学意义(P<0.05)。基线时患者信息处理速度评分、词语流畅性评分及记忆能力评分均与阴性症状评分呈负相关,信息处理速度评分与PANSS总分呈负相关(P<0.05)。6周后患者认知功能各项评分与疾病特征、精神症状各项评分均无线性相关关系(P>0.05)。6周后阴性症状影响因素的多元线性回归分析结果显示,进入模型的变量有基线时氯丙嗪当量、基线时信息处理速度评分、基线时阴性症状评分(P<0.05)。结论精神分裂症患者认知功能受损和阴性症状之间关系是相对独立而又存在联系的。
Objective To investigate the relationship between cognitive deficits and negative symptoms in patients with schizophrenia. Methods 108 schizophrenic patients who received antipsychotic monotherapy in the outpatient department and the wards of Peking University Sixth Hospital between February 2011 and July 2014 were recruited as case group,and at the same time 100 healthy controls were enrolled as control group from communities in Beijing by using the convenience sampling method. At baseline,all the subjects were evaluated by using Digit Symbol Substitution Test（ DSST）,Animal Fluency Test（ AFT） and Wechsler Memory Scale- Revised（ WMS- R） to assess information processing speed,verbal fluency and memory（ cognitive function）. Psychiatric symptoms of all patients were assessed by the Positive and Negative Syndrome Scale（ PANSS）. After 6-week treatment,42 patients who still received antipsychotic monotherapy were evaluated by the above assessments again. Results The case group was significantly lower（ P〈0. 05） than the control group in the scores of information processing speed,verbal fluency and memory. After 6- week treatment,the scores of psychiatric symptoms improved significantly（ P〈0. 05）,including the total score of PANSS and factor scores. At baseline, the scores of processing speed, verbal fluency and memory were negatively correlated with negative symptoms,and the score of processing speed was negatively correlated with the total score of PANSS（ P〈0. 05）. While after 6- week treatment,the scores of cognitive function had no correlation with disease features and the scores of psychiatric symptoms（ P〉0. 05）. By using multiple liner regression analysis,we found the factors influencing thenegative symptoms after 6- week treatment were chlorpromazine equivalent at baseline, the scores of processing speed and negative symptoms at baseline（ P〈0. 05）. Conclusion Cognitive deficits and negative symptoms in patients with schizophrenia appear to be relatively independent but related with each other.
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第30期3666-3670,共5页
Chinese General Practice
基金
国家“973计划”科技计划项目(2011CB707805)
