摘要
用化学发光法进行测定,BW-755C明显抑制f-MLP、调理化酵母多糖A和A_(23187)诱导的大鼠PMNs活性氧生成,吲哚美辛作用极弱。硝苯吡啶、硫氮卓酮和戊脉安低浓度抑制A_(23187)诱导的PMNs活性氧生成,不抑制A_(23187)、诱导的PMNs内游离钙增加。PGE_1对f-MLP诱导的PMNs活性氧生成有选择性的抑制作用。
By the method of chemiluminescence, it was showed that BW-755C strongly inhibited the generation of active oxygen in PMNs stimulated by f-MLP, A23187 or opsonized zymosan A, while the inhibitory effect of indomethacin was quite weaker, Nifidipine, diltiazem and verapamil inhibited the generation of active oxygen in PMNs stimulated by A23187 at low concentration, but they did not block intracel-lular calcium ion increase stimulated by A23187. PGE1 was shown in to be a selective inhibitor of f-MLP-induced active oxygen production PMNs.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第2期121-124,共4页
Chinese Pharmacological Bulletin
关键词
吲哚美辛
钙通道阻滞药
Indomethacin
BW-755C
Calcium channel blocker
Prostaglandin
Polymorphoneuclear leukocytes
Active oxygen
