摘要
本文报道了~3H-抗瘤酮A10经1次灌胃及静脉注射后在鼠体内的药物动力学研究。实验给出了有关动力学参数,如t1/2β 16.5±3.5h,Vd61.42ml,β0.0435±0.0090h^(-1),α为0.1953±0.0745h^(-1);建立了数学模型;其血药浓度—时间曲线符合双室模型。抗瘤酮A10在体内分布以肝、肾、胃、生殖器、膀胱最高;在脂肪、肠、肌肉和脑中亦有较高浓度。
This paper describes the pharmacokinetic properties of 3H-labelled Antineoplaston A10 ( AlO)following oral and intravenous administration in rats. The pharmacokinetic parameters were given and mathematical model was established by experiments . It was observed that the, concentration-time curves in blood accord with dicompart-ment model of pharmacokinetics . Organ distribution studies indicated greatest accumulation of radioactivity in liver, kidney, stomach, genitals and bladder and relatively high accumulation in fat, intestine, muscle and brains .
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第1期60-62,共3页
Chinese Pharmacological Bulletin
