摘要
使用浮置式细胞内微电极方法,结合肌力换能器,观察了呋喃苯胺酸(Furosemide,Fur6×10^(-4)mol/L)对蟾蜍离体心肌电及机械活动的影响。结果显示:Fur作用20min时使右心房收缩力(FC)增加到147.50%;动作电位幅值(APA)、O相上升最大速率(V_(max))及动作电位时程(APD_(50))分别增加到108.69%、106.58%及103.45%。对APD_(25)、APD_(90)及窦性周长(SCL)无明显影响,Fur的正性肌力作用能被维拉帕米(Verapamil,Ver2.2×10^(-7)mol/L)所取消。实验结果提示Fur具有促进Ca^(2+)内向电流的作用。
Using floating microelectrode, the effects of furosemide on action potential and contractile force were studied in isolated toad atrial myocardium. Furosemide increased the force of contraction of toad right atrial myocardium, amplitude and dV/dtmax of action potential, and prolonged action potential duration at 50% repolari-zation (APD50), but the APD25, APD90 and sinus cycle length ( SCL) were not influenced. The positive intropic effect of furosemide could be blocked by Verapamil. These results indicated that furosemide could promote the Ca++ inward current.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第1期40-42,共3页
Chinese Pharmacological Bulletin
关键词
呋喃苯胺酸
蟾蜍
心肌活动
Furosemide
Verapamil
Atrial myocardium
Action potential
Contractile force
