摘要
本文报道蝙蝠葛碱(Dau)对猫缺血和非缺血心脏MAP和FRP的影响及其抗心律失常作用。剂量依赖性延长猫左心室MAPD_(50)和MAPD_(90)及FRP,累积剂量9mg/kg时,分别由给药前的170±19ms,216±16ms和177±15ms延长至197±20ms,249±18ms和238±20ms。Dau5mg/kg iv,然后以0.1mg/kg·min^(-1)恒速灌注30min,可防止缺血边缘区MAPD_(50)缩短,使缺血边缘区,中心区和非缺血区FRP延长,并降低3个区域间FRP离散程度和LAD结扎和复灌引起的VF发生率和死亡率。
Dauricine ( Dau ) significantly prolonged monophasic action potential duration of 50% and 90% repolarization ( MAPD50 and MAPD90 ) and functional refractory period (FRP)of the hearts in anesthetized cats in dose-dependent manner. At 9 mg/kg of Dau, MAPD50 was increased from 170±19 ms to 197±20 ms; MAPD90 from 216±16 ms to 249±18 ms; FRP from 177 ± 15 ms to 238 ± 20 ms.
Dau 5 mg/kg iv followed by constant perfusion for 30 min could prevent the shortening of MAPD50 in the ischemic boundary area ( BA ) and increased FRP in the non-ischemic area ( NA ) , ischemic central area ( CA ) and BA, and markedly reduced the extent of dispersion of FRP of hearts in anesthetized cats. The results suggest that the antagonizing effect of Dau on the arrhythmias caused by acute myocardial ischemia and reperfusion might be related to its action of prolonging FRP and decreasing the dispersion of FRP in ischemic hearts.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第1期23-26,共4页
Chinese Pharmacological Bulletin
关键词
蝙蝠葛碱
抗心律失常药
Dauricine
Myocardial ischemia
Monophasic action potential
Functional refractory period
Antiarrhythmia
