摘要
结核病是由结核分枝杆菌复合群引起的慢性传染病。卡介苗是目前应用最广泛的抗结核疫苗,但其免疫保护效果并不理想。近年来,随着耐多药和泛耐药菌株的增多以及HIV合并感染等问题的日益凸显,抗结核新疫苗的研发势在必行。目前已有多种候选疫苗处于临床研究阶段,主要包括用于增强卡介苗免疫效力的蛋白亚单位疫苗和病毒载体疫苗、用于取代卡介苗的活疫苗及治疗性疫苗,其中亚单位疫苗的作用对象主要针对青少年及成人,因其对全球结核病疫情影响最大,当前阶段备受关注。本文就近年新型结核疫苗的研究进展作一综述。
Tuberculosis（TB）is a chronic infectious disease caused by Mycobacterium tuberculosis complex. At present,Bacillus Calmette-Guérin（BCG） is the most widely used vaccine against TB, though its immune protection is less ideal.Along with the increases of multi-drug and extensive-drug resistant strains and increasing seriousness of problems such as co-infection of HIV, it is imperative to develop novel TB vaccines. Considerable progress in some novel TB vaccines which mainly include protein adjuvant booster vaccines, viral-vectored booster vaccines, priming vaccines and therapeutic vaccines have been achieved in decades. Therein, booster vaccines targeting adolescents and adults have attracted significant attention because of their significant effects on epidemic of tuberculosis worldwide. This review outlines the progress in research on novel TB vaccines in recent years.
出处
《中国生物制品学杂志》
CAS
CSCD
2017年第10期1101-1106,共6页
Chinese Journal of Biologicals
关键词
结核病
结核疫苗
亚单位疫苗
病毒载体疫苗
Tuberculosis （TB）
Tuberculosis vaccine
Subunit vaccine
Viral-vectored vaccine
