摘要
目的观察奥施康定用于中重度癌痛止痛滴定的有效性及不良反应。方法 60例中重度癌痛患者随机分成两组:对照组接受吗啡即释片10 mg q4 h滴定,观察组接受奥施康定10 mg q12 h滴定。观察比较24 h内两组的疗效和不良反应发生率。结果滴定4 h时,对照组的疼痛缓解率为59.26%,低于观察组的79.31%(P<0.05);24 h后,对照组的疼痛缓解率为81.48%,观察组为86.21%,两组疼痛缓解率差异无统计学意义(P>0.05)。所有患者的不良反应为便秘、恶心呕吐、头晕、排尿困难、腹胀和厌食,经对症处理后均能耐受。结论奥施康定用于中重度癌痛患者止痛滴定与吗啡即释片效果相当,且简便、快速。
Objective To explore the effect and adverse effects of oxycodone hydrochloride extended-release tablets in the titration of moderate and severe cancer pain. Methods Sixty patients suffering from moderate and severe cancer pain were divided into two groups: control group used short-acting morphine tablets 10 mg per 4 h to start titration,experimental group used oxycodone hydrochloride extended-release tablets 10 mg per 12 h. The effects and adverse effects of two groups within 24 hours were observed and compared. Results After 4 hours of titration,pain-relieving objective response rate of control group was59. 26%,while experimental group was 79. 31% with statistically significant differences( P < 0. 05). After 24 hours of titration,the efficiency was 81. 48% in control group and 86. 21% in experimental group,and the difference was no statistically significance( P > 0. 05). The main adverse reactions of patients were constipation,nausea and vomiting,dizziness,dysuria,abdominal distension and anorexia apocleisis,and the symptoms all can be tolerated after symptomatic treatment. Conclusion Oxycodone hydrochloride extended-release tablets are effective,convenient and rapid in titration of moderate and severe cancer pain.
出处
《河南医学研究》
CAS
2017年第1期19-21,共3页
Henan Medical Research
关键词
奥施康定
癌痛
滴定
oxycodone
cancer pain
titration
