摘要
目的了解新生儿急性细菌性结膜炎的致病菌，寻找有效的抗菌药物，为临床提供合理的治疗方案。方法对159例经确诊为急性细菌性结膜炎新生儿的结膜囊分泌物进行细菌培养和药敏试验，对研究结果进行分析。结果新生儿急性细菌性结膜炎的细菌培养阳性结果为130例，阳性检出率为81．8％，不同年份（2013—2016年）检出的细菌阳性率差异无统计学意义（x2=0．695，P〉0．05）。表皮葡萄球菌（48．5％）、腐生葡萄球菌（22．3％）、淋球菌（38．7％）、肺炎克雷伯菌（32．3％）均是新生儿急性细菌性结膜炎的主要病原菌，菌株对红霉素、新霉素、青霉素和利福平耐药率高，对喹喏酮类和头孢类药物耐药率低。结论对新生儿急性细菌性结膜炎结膜囊分泌物进行细菌培养和药敏试验，有助于提高用药的治疗效果，减少病原菌的耐药性。
Objective To understand the pathogenic bacteria of neonatal acute bacterial conjunctivitis, and find ef- fective antibacterial agents for rational treatment. Methods Bacterial culture and drug sensitivity tests were performed using the conjunctival sac secretion from 159 neonates diagnosed with acute bacterial conjunctivitis. The results were analyzed. Results A total of 130 neonates showed positive bacterial culture, with the positive rate of 81.1%. No statistical difference was found among different years （X2 = 0. 695, P 〉 0：05 ）. The main pathogens of neonatal acute bacterial conjunctivitis were Staphylococcus epidermidis （ 48. 5% ）, Staphylococcus aureus （ 22. 3% ）, Neisseria gonorrhoeae （ 38.7% ） and Klebsiella pneumoniae （ 32.3% ）. The resistance rate was high to erythromycin, neomycin, penicillin and rifampin, but low to quinolones and cephalosporins. Conclusions Bacterial culture and drug sensitivity test using the conjunctival sac secretion in neonate with acute bacterial conjunctivitis facilitate to improve efficacy and reduce resistance.
出处
《徐州医科大学学报》
CAS
2017年第10期645-647,共3页
Journal of Xuzhou Medical University
基金
海南省自然科学基金（817361）
海南省医药卫生科研项目（16A200007）
关键词
新生儿
结膜炎
细菌培养
药敏试验
neonate
conjunctivitis
bacteria culture
drug sensitive test
