摘要
为稳定体内血浓,延长美托洛尔作用时间,避免频繁给药,研制了美托洛尔膜控片,并与美国Geigy公司缓释片及华瑞制药有限公司的普通片进行了体内药动学比较,体内血浓用GC-ECD法测定,体内动态过程符合单室模型,经计算机用Gauss-Newton-Damping法处理求得药动学参数。
A membrane controlled release tablet was developed in order to improve the bioavailability of metoprolol and avoid frequent administration. The dissolution profile could be discribed by the first order kinetics. The comparative bioavailability and plasma levels of metoprolol administered as membrane controlled release tablet (MCRM), conventional tablet (Astra, CMT)and sustained-release tablet (Geigy, SRM) were compared in 12 healthy volunteers after single dose. The determination of metoprolol in vivo was carried out by GC-ECD. The blood concentration-time course fitted with one compartment model. The bioavailability of MCRM to SRM and CMT was 144.4% and 248.2% respectively.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1991年第6期341-344,共4页
Journal of China Pharmaceutical University
关键词
美托洛尔
膜控片
制备
药物动力学
Metoprolol
Membrane controlled release tablet
GC-ECD
Bioavailability
