摘要
目的探讨吸烟、饮酒、慢性病、空腹血糖水平、尿酸等危险因素与泌尿系结石形成的相关性。方法通过1∶1匹配病例-对照设计,随机从武汉大学中南医院泌尿外科2015年5月至11月就诊459名泌尿系结石患者中抽取150例,以能获得完整数据信息的患者作为病例组,对照组为性别、民族、婚姻状态与病例组匹配的泌尿科非结石住院患者。采用单变量分析及条件Logistic的方法对两组数据进行统计分析。结果共纳入125例泌尿系结石患者和125例对照患者。泌尿系结石患者高峰发病年龄为50~70岁;男性占所有结石患者的70.75%;单侧结石占所有结石患者的62.24%。多因素回归分析结果显示,仅高血尿酸与发生泌尿系结石相关[OR=5.19,95%CI(2.27,11.91),P<0.01]。结论高尿酸血症是发生泌尿系结石的高危因素之一。
Objective To investigate the correlation between smoking, alcohol, chronic diseases, fasting plasma glucose levels, uric acid and the incidence of urolithiasis. Methods A 1 ： 1 pair-wise matching design was used in case-control study. We randomly selected 150 samples from 459 patients with urolithiasis in Zhongnan Hospital of Wuhan University from May 2015 to November 2015. Patient with intact information were identified as case group. The control group were patients who hospitalized in the same period without urolithiasis matched by gender, ethnic, and marital status. Univariate ANOVA and multivariate conditional logistic regression were used to test the differences between the two groups. Results A total of 125 patients in case group and 125 patients in control group were included. The peak age of urolithiasis was 50 to 70 years old, male patients accounted for 70.75% of the population, and one side urolithiasis accounted for 62.24% of the stone types. The results of multivariate conditional logistic regression showed that hyperuricemia was the related factor of urolithiasis （OR=5.19, 95%CI 2.27 to 11.91, P〈0.01）. Conclusions Hyperuricemia is one of the high risk factors for urolithiasis.
出处
《中国循证医学杂志》
CSCD
2017年第10期1131-1134,共4页
Chinese Journal of Evidence-based Medicine
基金
湖北省自然科学基金(编号:2014CFA006)
