摘要
DNA损伤普遍发生在细胞生命活动中,其可能导致细胞突变、癌变甚至死亡。发生在细胞周期内不同时期的DNA损伤可激活不同损伤检验点通路来阻滞或延迟细胞周期进展,为DNA损伤修复提供时间。若DNA损伤不能被修复,则由凋亡通路介导细胞凋亡。因此DNA损伤检验点通路对DNA损伤后细胞存亡与否至关重要。本文总结近年关于细胞对DNA损伤产生的应答机制的研究,如DNA损伤检验点、DNA损伤修复、转录反应和细胞凋亡。着重阐述在DNA损伤后,DNA损伤检验点通路活化及发挥作用的机制。旨在促进读者对DNA损伤检验点通路重要意义的理解,为探索DNA损伤检验点通路在肿瘤放化疗中的应用提供理论基础。
A damage is a general event in the life of cells and may lead to mutation,cancer,and cell/organ death. DNA damage occurring in different phases of cell cycle can activate different damage checkpoint pathways to halt the progress of cell cycle in order to provide time for DNA damage repair. If DNA damage cannot be repaired,cellular apoptosis may be induced. Therefore,DNA damage checkpoint is of great significance for cell survival after DNA damage. This article summarizes recent research on DNA damage responses,including DNA damage checkpoint,DNA damage repair,transcriptional response,and cell apoptosis. We focus on how the DNA damage checkpoint pathway is activated after DNA damage,as well as the functional mechanism of the DNA damage checkpoint pathway. The review aims to help readers understand the great significance of DNA damage checkpoint pathway,providing a theoretical basis for its application in radiotherapy and chemotherapy for cancer.
作者
周聪雅
张丹
韩苏夏
Zhou Congya Zhang Dan Han Suxia(Department of Radiation Oncology , First Affiliated Hospital of Xi＇ an Jiaotong University, Basic Medical College of Xi＇an Jiao Tong University , Xi＇ an 710061, China)
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2017年第10期1231-1235,共5页
Chinese Journal of Radiation Oncology
基金
国家自然科学基金（81272488、81472795、81450110450、81572968）
陕西省国际合作项目（2012KW-42-01）
