摘要
目的:研究共济失调毛细血管扩张症突变基因蛋白(ATM蛋白)在淋巴结阴性的进展型食管癌组织及其癌旁正常的鳞状上皮中的表达情况,探讨其在食管癌发生中的作用。方法:采用免疫组化SP法,检测ATM蛋白在淋巴结阴性的进展型食管癌组织及其癌旁正常的鳞状上皮中的表达。结果:ATM蛋白在淋巴结阴性的进展型食管癌组织及其癌旁正常的鳞状上皮中的表达情况分别为60%、95%,二者的比较具有统计学意义(P=0.02)。结论:ATM蛋白在食管癌组织中表达下降,并可能在食管癌的发生中起一定作用。
Objective： To study the expression of ATM in lymph node- negative advanced esophageal cancer and its expression in normal squamous epithelium of the adjacent to carcinoma and its role in progession of esophageal cancer. Methods： By using immunohistochemical SP method,to detect expression of ATM protein in lymph node-negative advanced esophageal cancer tissues and adjacent normal squamous epithelium. Results： The expression of ATM in lymph node- negative advanced esophageal cancer and its expression in normal squamous epithelium of the adjacent to carcinoma were 60%,95%（ P = 0. 02）. Conclusion： The expression of ATM in advanced esophageal cancer was decreased,and ATM may play a role in the progression of esophageal cancer.
出处
《现代肿瘤医学》
CAS
2014年第12期2873-2874,共2页
Journal of Modern Oncology
基金
淮安市科技支撑计划(社会发展)项目(编号:HAS2012017)
