摘要
目的探究新生儿科住院患儿医院感染的病原学特点及危险因素,进一步形成有效预防对策。方法选择2015年10月-2016年10月医院新生儿科收治的3370例新生儿作为研究对象,回顾分析胎龄、出生体质量、侵入性操作、感染前使用抗菌药物或激素、喂养方式、分娩方式、住院时间等资料,探究病原学特点,并对新生儿院内感染的危险因素进行单因素及多因素分析,形成有效预防对策。结果 3370例新生儿共发生医院感染60例,感染率为1.78%;共培养病原菌60株,其中革兰阴性菌38株占63.33%,以肺炎克雷伯菌为主,革兰阳性菌19株占31.67%,以葡萄球菌为主,真菌3株占5.00%;多因素logistic研究结果显示,胎龄<37周、非自然分娩、出生体质量<2500g、肠外营养、侵入性操作、住院时间长以及感染前使用抗菌药物或激素等,是新生儿院内感染的独立危险因素。结论通过对新生儿院内感染临床资料分析,探究病原学特点和危险因素,总结有效预防措施,以减少新生儿院内感染。
OBJECTIVE To analyze the etiological characteristics,risk factors and preventive strategies of nosocomial infections in hospitalized children of neonatal department.METHODS From Oct.2015 to Oct.2016,3370 neonates in neonatal department of the hospital were selected as research subjects.The gestational age,birth weight,invasive operation,use of antibiotics or hormones,feeding modes,delivery modes,and length of hospitalization were retrospectively analyzed,the etiological characteristics were explored,and the risk factors were analyzed by univariate and multivariate logistic regression analysis,so as to form effective preventive strategies.RESULTS There were 60 cases of nosocomial infections（1.78% ）,and 60 strains of pathogens were cultrured,including 38 strains of gram-negative bacteria（63.33% ）,which were mainly Klebsiella pneumoniae,19 strains of gram-positive bacteria（31.67% ）,which were mainly Staphylococcus,and 3strains of fungi（5.00% ）.Multivariate logistic analysis showed that,gestation 37 weeks,non natural childbirth,birth weight2 500 g,parenteral nutrition,invasive operation,long length of hospitalization and use of antibiotics or hormones before infections were independent risk factors of nosocomial infection in neonates.CONCLUSION We explore the etiological characteristics and risk factors by analyzing the clinical data of neonatal nosocomial infections,so as to form the effective preventive measures to reduce neonatal nosocomial infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第18期4228-4231,共4页
Chinese Journal of Nosocomiology
基金
浙江省医药卫生科技计划基金资助项目(2013KYB240)
关键词
新生儿
院内感染
危险因素
预防
Newborn
Nosocomial infection
Risk factors
Prevent
