摘要
目的探讨盐酸戊乙奎醚注射液(商品名:长托宁)与阿托品联合应用治疗有机磷农药中毒的临床疗效。方法 60例有机磷农药中毒患儿,以随机数字表法分为观察组和对照组,每组30例。观察组患儿先给予阿托品达阿托品化后给予戊乙奎醚维持治疗,对照组患儿单纯给予阿托品治疗。对比两组患儿的急救治疗效果及急救指标[机械通气治疗时间、神志清醒所需时间、儿童重症监护病房(PICU)住院时间、血清胆碱酯酶(CHE)活力恢复60%时间、pH值、动脉血氧饱和度(SaO_2)、动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)]转归情况。结果观察组患儿的急救总有效率为93.3%,高于对照组的73.3%,差异具有统计学意义(P<0.05)。观察组患儿的机械通气治疗时间、神志清醒所需时间、PICU住院时间、CHE活力恢复60%时间均短于对照组,pH值、PaCO_2低于对照组,SaO_2、PaO_2高于对照组,差异均具有统计学意义(P<0.05)。结论戊乙奎醚与阿托品联合应用治疗有机磷农药中毒可显著提高患儿的急救成功率,对患儿的各项急诊急救指标的转归具有显著的促进作用。
Objective To investigate the clinical efficacy of penehyclidine hydrochloride injection（trade name：Changtuoning） combined with atropine in the treatment of organophosphorus pesticide poisoning.Methods A total of 60 organophosphorus pesticide poisoning children were divided by random number table method into observation group and control group,with 30 cases in each group.The observation group received atropine first then penehyclidine maintenance therapy after ＂atropinization＂,and the control group received only atropine.Comparison were made on emergency treatment effect and emergency indexes [mechanical ventilation time,conscious time,pediatric intensive care unit（PICU） hospitalization time,serum cholinesterase（CHE） activity recovered 60% time,p H value,arterial oxygen saturation（SaO2）,arterial oxygen pressure（PaO2） and arterial partial pressure of carbon dioxide（PaCO2）] outcome in two groups.Results The observation group had higher total emergency effective rate as 93.3% than 73.3% in the control group,and their difference had statistical significance（P〈0.05）.The observation group had shorter mechanical ventilation time,conscious time,PICU hospitalization time and CHE activity recovered 60% time than the control group,lower p H value and PaCO2 than the control group and higher SaO2 and PaO2 than the control group.Their difference had statistical significance（P〈0.05）.Conclusion Combination of penehyclidine and atropine in treating organophosphorus pesticide poisoning can significantly improve the emergency success rate of children,and it has a significant effect in promoting the outcome of emergency first aid indicators in children.
作者
杨春
YANG Chun(Department of Pediatrics, Yunnan Province Puer City People＇ s Hospital Maternity and Child Hospital, Puer 665000, Chin)
出处
《中国实用医药》
2017年第25期119-121,共3页
China Practical Medicine
关键词
戊乙奎醚
阿托品
有机磷农药中毒
Penehyclidine
Atropine
Organophosphorus pesticide poisoning
