摘要
与以往肿瘤经典治疗手段不同,肿瘤免疫治疗的焦点从肿瘤本身转为动员宿主免疫系统去识别并消灭肿瘤细胞。近年来,针对免疫检查点的单克隆抗体在临床应用中取得了飞速进展,随之而来的是各种耐药问题的出现。文章针对各种耐药分子机制以及相关临床应用作一具体阐述。
The focus of tumor immunotherapy has been shifted from tumor itself to host immune system,which is different from conventional tumor therapy.In recent years,the monoclonal antibodies against immune checkpoints have made rapid progress in clinical applications,nevertheless the related drug resistance also appears.This article reviews the resistance mechanism of immune checkpoints drugs and related clinical implications.
作者
许斌
胡梦雪
宋启斌
XU Bin HU Meng-xue SONG Qi-bin(Wuhan University Renmin Hospital, Wuhan 430060, China The First Clinical School of Wuhan University, Wuhan 430060, China)
出处
《中国肿瘤》
CAS
CSCD
2017年第9期707-713,共7页
China Cancer
基金
武汉大学2016年度自主科研项目(自然科学类)(2042016kf0088)
关键词
免疫治疗
免疫检查点抑制剂
耐药机制
肿瘤
临床应用
immunotherapy
immune checkpoint inhibitors
resistance mechanism
tumor
clinical application
