摘要
目的分析天津市中老年文职职业群体血脂水平随年龄变化趋势及性别差异。方法选择2016年1—12月在天津市第一中心医院查体科进行健康体检的天津市在职及离退休文职人员,调查基础病史,测身高、体质量、血压,并标准化测定血清总胆(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),将研究对象按年龄及性别分组:~50岁组、51~60岁组、61~70岁组、71~80岁组、81~岁组,分析该群体血脂水平及其随年龄变化规律。结果入选~50岁组1 237例,51~60岁组1 582例,61~70岁组968例,71~80岁组931例,81~岁组715例。男性~50岁组TG水平高于余下高年龄组,81~岁组TC水平低于51~60岁组和61~70岁组。~50岁组、51~60岁组的HDL-C水平低于61~70岁组、71~80岁组,而51~60岁组、61~70岁组的LDL-C水平高于~50岁组(P<0.05);女性~50岁组TG、TC及LDL-C水平均低于同性别高年龄组,HDL-C水平低于51~60岁组(P<0.05)。女性~50岁组、51~60岁组TG水平低于同年龄男性组,而71~80岁组、81~岁组高于同年龄男性。除~50岁组外,女性TC、LDL-C水平均高于同年龄男性组;各年龄组女性HDL-C水平均高于男性(P<0.05)。结论 TG、TC、LDL-C水平与HDL-C水平变化趋势不完全一致,TC、LDL-C呈先升后降的趋势,HDL-C呈升高趋势,TG水平在男性随增龄而降低,在女性随增龄呈升高趋势。提示雌激素对血脂的影响可能存在更复杂的作用机制。
Objective To explore the gender differences and age-related change of serum lipid level of middle-aged and elderly civilian personnel in Tianjin. Methods Recorded medical history,height and weight,blood pressure,total cho- lesterol（TC）, triglycerides （TG）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） of population from Tianjin First Center Hospital for annual health check during January to December 2016 were included. According to age （10 years per group） and gender, who were divided into several groups, and the blood lipid lev- els and their change with age were analyzed. Results There were 1 237 cases included in -50 years group, 1 582 cases included in 51-60 years group,968 cases in 61-70 years group,931 cases in 71-80 years group,715 cases in 81- years group. In all male groups,the TG level of -50 years group were higher than other elderly groups,TC level of male 81-years group was lower than 51-60 years group and 61-70 years group. HDL-C level of -50 years group and 51-60 year group were lower than those of 61-70 years group and 71-80 years group,while LDL-C levels of 51-60 years group,61-70 years group were higher than that of -50 years group （P 〈 0.05 ）. In all-female groups, TG, TC and LDL-C level in -50 years group were significantly lower than those of other elderly groups, and HDL-C lower than 51-60 years group as well（P 〈 0.05）. The TG level of female -50 years group,S1-60 years group were lower than those of the male group of the same age bracket,however in the 71-80 years group and 80- years group the opposite results were observed. Compared with the same age group,the results showed that TC, LDL-C level of female groups were significantly higher than those of the male groups of all age brackets except -50 years group, HDL-C level of female groups was higher than that of the male groups in all same age brackets（P 〈0.05）. Conclusion The trend of the change of TG, TC, LDL-C and HDL-C were not all the same. The TC and LDL-C level rises at first, then decreases with increasing age, HDL-C increases gradually, TG level has a trend of gradualdecrement in male, and rises with increasing age in female, which indicates that the relation between estrogen and lipid levels may be more complex.
作者
罗迪
卞爱琳
梁钢
王小飞
LUO Di BIAN Ailin LIANG Gang WANG Xiaofei.(International Center for Diagnosis and Treat- ment, Tianjin First Center Hospital, Tianjin 300192 ,China)
出处
《医学综述》
2017年第18期3725-3728,共4页
Medical Recapitulate
关键词
血脂异常
老老年
雌激素
心血管疾病
Dyslipidemia
Very elderly
Estrogen
Coronary heart disease
