摘要
1,2,4-三氮唑具有多种生物活性,广泛存在于药物分子中。1,2,4-三氮唑类化合物可通过阻断脂质的生物合成和/或其他的作用机制抑制结核分枝杆菌生长,故这类化合物在抗结核新药的研发中占据了相当重要的位置。本文将着重介绍近年来1,2,4-三氮唑类化合物在抗结核领域的研究进展,并讨论此类化合物的构-效关系。
1,2,4-Triazole motif which existed in many drugs, exhibited various biological activities. 1,2,4-Triazole derivatives emerged as a new class of effective anti-tubercular candidates owing to their potential ability to inhibit the growth of bacteria by blocking lipid biosynthesis and/or additional mechanisms. Thus, 1,2,4-triazole derivatives occupy an important position in developing new anti-tubercular agents. This review outlines the advances in the application of 1,2,4-triazole derivatives as anti-tubercular agents and structure-activity relationship of these derivatives.
出处
《国外医药（抗生素分册）》
CAS
2017年第5期230-237,共8页
World Notes on Antibiotics
关键词
1
2
4-三氮唑
结核
分枝杆菌:构.效关系
1,2,4-triazole
tubercular
anti-mycobacterial
structure-activity relationship
