摘要
以芳香醛、乙酰乙酸乙酯(甲酯)、单取代脲为原料,氯化亚锡为催化剂,在无溶剂、80℃条件下,通过三组分"一锅法"合成了一系列N1-取代的3,4-二氢嘧啶-2(1H)-酮衍生物。考察了催化剂用量和反应温度对产品收率的影响。通过IR、~1H NMR、^(13)C NMR和元素分析对目标产物结构进行确证,提出了可能的催化作用机理。本文的合成方法具有催化剂活性高、廉价易得和反应时间短、条件温和、产率高、绿色环保等优点。
N1-Substituted 3,4-dihydropyrimidin-2（ 1H）-ones were synthesized by a SnCl2 catalysed three components one-pot reaction using aromatic aldehydes,ethyl acetoacetate（ methyl acetoacetate） and monosubstituted urea as raw materials under solvent-free conditions. Effects of the amount of catalyst and the reaction temperature on the yields of product were studied. The structures of the titled products were characterized by IR,~1H NMR,^（13） C NMR and elemental analysis. A mechanism to rationalize the reaction was proposed. This synthetic method has the advantages of short reaction time,mild reaction conditions,high yield,high catalytic activity,inexpensive catalyst and environmentally benign etc.
出处
《化学通报》
CSCD
北大核心
2017年第9期863-867,共5页
Chemistry
基金
国家自然科学基金项目(21406016)
辽宁省高等学校优秀人才支持计划项目(LJQ2015002)
辽宁省自然科学基金项目(2015020201)资助
