摘要
目的分析老年中晚期宫颈癌患者放化疗期间发生院内感染的危险因素。方法回顾性分析2013年1月至2016年1月于本院住院治疗的128例年龄≥60岁且国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期≥Ⅲ期的宫颈癌患者的临床资料。将放化疗期间发生院内感染的68例患者纳入观察组,将未发生院内感染的60例患者纳入对照组。分析老年中晚期宫颈癌患者放化疗期间发生院内感染的危险因素。结果观察组中10例患者感染部位多于2个,其中以胃肠道最多,其余依次为呼吸道、生殖道、泌尿道、盆腹腔及皮肤。患有糖尿病和(或)肺部疾病、血清白蛋白水平<35 g/L、白细胞计数<2×10~9/L、T淋巴细胞异常(CD3^+T淋巴细胞<0.5或CD4^+/CD8^+T细胞<1.4)、住院总次数>6次及住院总天数>30天是老年中晚期宫颈癌患者放化疗期间发生院内感染的独立危险因素(P<0.05)。结论临床应对体质较差、伴有糖尿病和肺部疾病等基础疾病的老年患者格外谨慎,采取综合措施提高患者营养状况和抵抗力,减少治疗次数,缩短住院天数,降低院内感染发生率。
Objective To analyze the risk factors of nosocomial infection of elderly patients with advanced cervical cancer during radiochemotherapy.Method Retrospective analyzed the clinical data of 128 cases aged more than 60 years old and the International Federation of Gynecology and Obstetrics （FIGO） stage≥Ⅲ of cervical cancer patients from January 2013 to January 2016 in our hospital. 68 patients with nosocomial infection during radiochemotherapy were included into observation group, and 60 patients without nosocomial infection were included into control group. The clinical information were analyzed to evaluate the risk factors of nosocomial infection in elderly patients with advanced cervical cancer during radiochemotherapy.Result There were 10 cases of patients with more than 2 sites of infection in observation group, the location of infection was most gastrointestinal, the other infection sites were respiratory tract, reproductive tract, urinary tract, pelvic cavity, abdominal cavity and skin. Suffered from diabetes and （or） lung disease, serum albumin level〈35 g/L, white blood cell count〈2×10^9/L, T lymphocyte were abnormal （CD3^＋T cells〈0.5 or CD4^＋/CD8^＋T〈1.4）, the total number of hospitalization〉6 times and total hospitalization〉30 days were independent risk factors of nosocomial infection in elderly advanced cervical cancer patients during radiochemtherapy （P〈0.05）.Conclusion We should pay much attention to the elderly advanced cervical cancer patients during radiochemotherapy, and apply multiple methods to improve nutritional status and resistant capability, reduce the incidence rate of nosocomial infection.
出处
《中国医学前沿杂志（电子版）》
2017年第7期144-147,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
四川省卫生厅科研课题(30325561465)
关键词
宫颈癌
老年患者
放化疗
院内感染
Cervical cancer
Elderly patients
Radiochemtherapy
Nosocomial infection
