摘要
目的探讨右美托咪定联合舒芬太尼术后镇痛在宫颈癌根治术患者中的应用效果。方法根据术后镇痛方式的不同将80例宫颈癌根治术患者分为对照组(n=40)和观察组(n=40),对照组患者术后采取舒芬太尼多模式镇痛,观察组患者在对照组的基础上联合右美托咪定镇痛。比较两组患者自控镇痛(PCA)泵有效按压次数、疼痛程度[视觉模拟评分法(VAS)]、睡眠质量及镇静程度。结果术后1、2天,观察组患者的PCA泵有效按压次数均明显少于对照组(P﹤0.01)。术后1、6、12、24、48 h,两组患者的VAS评分均呈降低趋势,观察组患者的VAS评分均低于对照组,差异均有统计学意义(P﹤0.05)。术前,两组患者的深睡眠质量评分比较,差异无统计学意义(P﹥0.05);术后24、48 h,观察组患者的深睡眠质量评分均明显低于对照组,差异均有统计学意义(P﹤0.01)。术后1、6、12、24、48 h,两组患者的Ramsay镇静评分均呈降低趋势,观察组患者的Ramsay镇静评分均明显高于对照组,差异均有统计学意义(P﹤0.01)。结论右美托咪定联合舒芬太尼用于宫颈癌根治术后镇痛,能够减轻患者疼痛,改善患者的睡眠质量,提高镇静及镇痛效果。
Objective To investigate the application effect of postoperative analgesia by dexmedetomidine combined sufentanil in patients undergoing radical resection of cervical cancer.Method A total of 80 patients with cervical cancer undergoing radical resection were divided into control group(n=40,received postoperative analgesia of sufentanil)and observation group(n=40,received postoperative analgesia of dexmedetomidine+sufentanil)according to different postoperative analgesia methods.The effective pressing times of patient-controlled analgesia(PCA)pump,pain degree[visual analogue scale(VAS)],sleep quality and sedation degree were compared between the two groups.Result At 1 and 2 days after surgery,the effective pressing times of PCA pump in the observation group were less than those in the control group(P<0.01).At 1,6,12,24,48 hours after surgery,the VAS scores in the two groups showed a decreasing trend,and the scores of the observation group were lower than those of the control group(P<0.05).There was no significant difference in the score of deep sleep quality between the two groups before surgery(P>0.05).At 24 and 48 hours after surgery,the scores of deep sleep quality in the observation group were lower than those of the control group(P<0.01).At 1,6,12,24,48 hours after surgery,the Ramsay sedation scores in the two groups showed a decreasing trend,and the scores in the observation group were higher than those in the control group(P<0.01).Conclusion Postoperative analgesia by dexmedetomidine combined with sufentanil can significantly relieve pain,improve sleep quality,sedation and analgesia effect after radical resection of cervical cancer.
作者
孙晓妮
张军
李思远
SUN Xiaoni;ZHANG Jun;LI Siyuan(Department of Anesthesiology,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710000,Shaanxi,China;Department of Anesthesiology,Xianyang Rainbow Hospital,Xianyang 712000,Shaanxi,China;Department of Anesthesia and Surgery,Xi’an International Medical Center Hospital,Xi’an 710000,Shaanxi,China)
出处
《癌症进展》
2022年第21期2229-2232,共4页
Oncology Progress
关键词
宫颈癌根治术
右美托咪定
舒芬太尼
疼痛程度
睡眠质量
镇静程度
radical resection of cervical cancer
dexmedetomidine
sufentanil
pain degree
sleep quality
sedation degree
