摘要
目的:观察布地奈德福莫特罗粉吸入剂对支气管哮喘患者血清白细胞介素17(IL-17)水平的影响,探讨其改善支气管哮喘病情的可能机制。方法:2016年1月-2017年1月就诊于贵州省中医医院支气管哮喘门诊患者60例,分为治疗组42例,对照组18例,同时设52例健康人为健康对照组。治疗组予以布地奈德福莫特罗粉吸入剂。对照组予沙美特罗替卡松吸入,治疗时间均为90d。检测治疗组、对照组及健康对照组静脉血中IL-17的表达水平。结果:治疗组血清IL-17水平的中位数及四分位间距为20.14(9.57~47.26)g/L,对照组为4.28(2.36-10.82)g/L,2组比较差异有统计学意义(P<0.01);治疗组轻、中、重度患者IL-17水平与病情呈正相关(P<0.05);治疗组在吸入布地奈德福莫特罗前IL-17水平为16.27(7.06-29.52)g/L,治疗后为8.16(5.21-16.14)g/L,治疗组治疗前后比较有统计学意义(P<0.01)。结论:支气管哮喘患者血清IL-17水平升高,布地奈德福莫特罗粉吸入剂可降低IL-17水平。
Objective：To observe the changes of serum interleukin 17 （IL-17）levels in patients with bronchial asthma and the effect of Budesonide and Formoterol Fumarate Powder for Inhalation on it. Method： A total of 60 patients with bronchial asthma who were diagnosed with bronchial asthma From January 2016 to January 2017 in our hospital diagnosed 60 cases of bronchial asthma patients, including 42 cases of treatment group （ including 25 cases of mild asthma group, 12 cases were moderate asthma group, severe asthma group 5 cases ）, 18 cases in the control group, healthy control group of 52 healthy people. The treatment group received Budesonide and Formoterol Fumarate Powder for Inhalation. The control group was treated with salmeterol fluticasone propionate inhalation. The expression level of IL-17 in venous blood of the treatment group, the control group and the healthy control group was detected.Result： The median serum IL-17 level of the treatment group and four points distance is 20.14 （ 9.57 - 47.26 ） g/L, the control group was 4.28 in the control group （ 2.36-10.82 g/L ）, there was significant difference between 2 groups （ P 〈 0.01 ） ; relative light, moderate and severe asthma group IL-17 level and severity of the disease was positive （ P 〈 0.05 ） in the treatment group; inhalation before Bbu Di Ned Fumo Tero IL-17 level was 16.27 （ 7.06-29.52 ） g/L after treatment was 8.16 （ 5.21-16.14 ） g/L, the treatment group before and after treatment were statistically significant （ P 〈 0.01.Conclu- sion： IL-17 levels are elevated in patients with bronchial asthma, and Budesonide and Formoterol Fumarate Powder for Inhalation can decrease the level of IL-17.
出处
《中医药临床杂志》
2017年第8期1313-1316,共4页
Clinical Journal of Traditional Chinese Medicine
基金
贵州省科学技术基金
项目编号2014[2035]号
