摘要
神经退行性疾病严重威胁着人们的健康。炎症在神经退行性疾病的发生与发展中始终扮演着重要角色,其主要特征是小胶质细胞的激活和炎性因子的水平升高。本文综述了神经炎症与多种退行性疾病的关系和体内外模型,并结合中医对"脑病"的认识,总结多种中药提取物及其单体化合物阻止小胶质细胞活化、抑制神经炎症的药理作用和机制,为逐步揭示中医治疗脑病"证-方-药"的相关规律、特征,提高临床用药的准确性和开发防治脑病的新药物提供基础。
Neurodegenerative diseases are threating our health seriously. Inflammation plays an important role in the initiation and development of neurodegenerative diseases,and its primary characteristics are the activation of microglia and the increasing level of inflammation cytokines. This review describes the relationship between neuroinflammation and several neurodegenerative diseases,and the models in vivo and in vitro. In addition,combining with traditional Chinese medicines knowledge of encephalopathy,we summarizes pharmacological effects and mechanisms of multiple herb extracts and monomer compounds in preventing the activation of microglia and inhibiting neuroinflammation,thus,to provide the basis for gradually revealing the related rules and characteristics of treating encephalopathy by traditional Chinese medicine,and improving the accuracy of the clinical drugs,as well as developing new drugs for the prevention and control of encephalopathy.
出处
《中国实验动物学报》
CSCD
北大核心
2017年第4期461-466,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金项目(81403171
81573649)
中国中医科学院中药研究所自选课题(QZPT001)
关键词
神经退行性疾病
神经炎症
中药
Neurodegenerative diseases
Neuroinflammation
Chinese medicine
