摘要
阿尔茨海默病(Alzheimer’s disease,AD)是老年人常见的神经退行性疾病,目前仍缺乏对其发病机制的深入理解以及有效药物的开发。钙敏感受体(calcium-sensing receptor,CaSR)广泛存在于人体中枢神经系统的各类细胞中,可溶性β-淀粉样蛋白(β-amyloid protein,Aβ)是CaSR的正构调节剂之一。CaSR参与Aβ的级联放大,介导Aβ引起的炎性因子的释放以及血管内皮细胞生长因子-A(vascular endothelial growth factor-A,VEGF-A)的过量产生。该文主要对CaSR在AD发病中的作用和机制进行综述,并对CaSR变构抑制剂在AD治疗中的可能作用进行了展望。
Alzheimer＇s disease（AD） is a common neurodegenerative disease in the elderly. Nowadays the pathogenesis of AD is unclear. There is still lack of effective drugs for this disease. Calcium-sensing receptor（CaSR） has been found in different kinds of cells in the central nervous system. Soluble β-amyloid protein（Aβ） is one of the positive allosteric modulators of CaSR. CaSR is involved in cascade amplification of Aβ, inflammatory factors and vascular endothelial growth factor-A（VEGF-A） which is caused by Aβ. In this review, we summarized the roles and mechanisms of CaSR in the pathogenesis of AD. CaSR allosteric inhibitors are expected to be potential drugs for AD in the near future.
作者
冯晨希
王媛媛
鲍晓明
沈苏燕
王钦文
徐淑君
Feng Chenxi Wang Yuanyuan Bao Xiaoming Shen Suyan Wang Qinwen Xu Shujun(School of Medicine, Ningbo University, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China Ningbo No.2 Hospital, Ningbo 315010, China)
出处
《中国细胞生物学学报》
CAS
CSCD
2017年第6期804-810,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81471398)
浙江省自然科学基金(批准号:LY16H090001)
宁波市自然科学基金(批准号:2015A610211)
宁波市生命健康科技创新团队–重大精神疾病转化医学(批准号:2015C110026)
宁波市人才工程项目和宁波大学王宽诚幸福基金资助的课题~~
