摘要
目的比较粒径分别为0.150,0.075,0.048,0.038 mm的活血散透皮吸收前后的大黄素、黄柏碱、小檗碱、药根碱的含量,确定活血散的最佳粒径。方法采用超高效液相-质谱联用技术,对不同粒径活血散透皮吸收液24 h内大黄素、黄柏碱、小檗碱、药根碱的含量进行测定,比较各有效成分的含量,确定活血散的最佳粒径。结果粒径0.075 mm的活血散各有效成分含量较高,透皮吸收后各有效成分含量也较高。结论活血散以粒径0.075 mm的散剂最佳。
Objective To optimize the particle size of Huoxue powder by contents comparison of emodin, phellodendrine,berberine and jatrorrhizine before and alter permeabilized skin absorption of Huoxue powder in different particle size of 0.150,0.075,0.048,0.038 mm. Methods The contents of emodin, phellodendrine, berberine and jatrorrhizine in transparent absorbent fluid of Huoxue power in different particle size within 24 hours were measured by ultra performance liquid chromatography tandem mass spectrometry,and optimize its particle size by contents comparison of the effective components.Results The contents of the active components in Huoxue power with the particle size of 0.075 mm were high before and after percutaneous absorption. Conclusion Particle size of 0.075 mm is best for Huoxue powder.KEY WORDS Huoxue powder;Phellodendrine;Berberine;Jatron, hizine;Ultra performance liquid chromatography tandem mass spectrometry;Percutaneous absorption;Emodin
出处
《医药导报》
CAS
2017年第9期1033-1037,共5页
Herald of Medicine
基金
南京市医学科技发展项目(YKK14141)
关键词
活血散
大黄素
黄柏碱
小檗碱
药根碱
超高效液相-色谱质谱联用
透皮吸收
Huoxue powder
Phellodendrine
Berberine
Jatron, hizine
Ultra performance liquid chromatography tandem mass spectrometry
Percutaneous absorption
Emodin
