摘要
目的探讨心房颤动导管消融术后早期复发与炎症反应和细胞外基质生物标志物间的关系。方法选取我院自2014年1月~2015年1月间收治的进行心导管消融术患者62例作为研究对象,测定该组患者手术前后高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶抑制剂-2(TIMP-2),对比术后早期复发患者和未复发患者各指标的水平差异。结果复发组患者和未复发组患者的房颤类型、性别、年龄差异无统计学意义(P>0.05);复发组患者术前IL-6、hs-CRP、MMP-2均显著高于未复发组,组间比较差异有统计学意义(P<0.05);两组术前TIMP-2指标差异无统计学意义(P>0.05)。结论心房颤动患者行RFCA治疗后早期复发与机体炎症反应、MMP-2水平变化息息相关,因此可以作为防治复发的判断依据。
Objective To investigate the relationship between early recurrenceafler catheter ablation of atrial fibrillation and inflammatory response, extracellular matrix biomarkers. Methods 62 patients who underwent cardiac catheter ablation from January 2014 to January 2015 in our hospital were selected.The high sensitivity C-reactive protein（hs-CRP）, intedeukin-6（IL-6）, matrix metalloproteinase-2（MMP-2） and tissue inhibitor of metalloproteinase-2（TIMP-2） in the patients before and after surgery were detected. The differences in the levels of each indicator between the early post- operative recurrence patients and non-recurrence patients were compared. Results The differences were no statistically significant in the type of atrial fibrillation, sex and age between the recurrence group and the non-recurrence group（P〉 0.05）. The levels of IL-6, hs-CRP and MMP-2 in the recurrence group were significantly higher than those of the non- recurrence group, and the differences were statistically significant（P〈0.05）. The difference was no statistically significant in the preoperative TIMP-2 between the two groups（P〉0.05）. Conclusion Early recurrence in patients with atrial fibrillation after undergoing RFCA treatment is closely related to the inflammatory response and the change of MMP-2 level, so it can be used as the basis for the prevention and treatment of recurrence.
作者
付蕾
孙国建
何浪
钟诚
欣明花
沈法荣
FU Lei SUN Guojian HE Lang ZHONG Cheng XIN Minghua SHEN Farong(Department of Cardiology, Green City Cardiovascular Hospital in Zhejiang Province, Hangzhou 310000, China)
出处
《中国现代医生》
2017年第24期26-29,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2014KYB213)
