摘要
目的探讨阿托伐他汀联合沙格列汀治疗2型糖尿病合并血脂异常的临床效果及安全性。方法选择医院收治的2型糖尿病合并血脂异常的患者62例,按治疗方法不同分为观察组与对照组,每组31例。观察组应用阿托伐他汀联合沙格列汀治疗,对照组仅给予沙格列汀治疗。观察2组治疗前后血脂、血糖及肝功能情况。结果治疗后观察组血脂水平改善情况优于对照组,差异有统计学意义(P<0.05)。治疗后2组血糖均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后2组肝功能指标比较差异无统计学意义(P>0.05)。结论阿托伐他汀联合沙格列汀治疗2型糖尿病合并血脂异常临床效果较好,可有效地改善患者糖、脂代谢紊乱情况,且不增加不良反应。
Objective To investigate the clinical efficacy and safety of atorvastatin and saxaglitin in the treatment of patient with type 2 diabetes mellitus and abnormal level of blood lipid. Methods 62 cases of T2DM in our hospital were selected and randomly divided into control group and treatment group with 31 cases in each group. The treatment group was given atorvastatin and saxagliptin and the control group was only conducted saxagliptin. The blood lipid, blood glucose and liver function were observed before and after treatment. Results After treatment, the improvement of blood lipid level in the observation group was better than that in the control group and the difference was statistically significant （P 〈 0. 05 ）. After treatment, the blood glucose of the ＇two groups was lower than that before treatment, and the observation group was lower than the control group. The difference was statistically significant （P 〈 0.05 ）. There was no significant difference in liver function between the two groups after treatment （P 〉 0. 05）. Conclusion Atorvastatin combined with saxagliptin in type 2 diabetes mellitus with dyslipidemia has a good clinical effect, which can effectively improve the disorder of patients＇ glucose and lipid metabolism without increasing the adverse reaction.
出处
《临床合理用药杂志》
2017年第23期7-8,共2页
Chinese Journal of Clinical Rational Drug Use
