摘要
目的 探讨卡前列素氨丁三醇对产后出血患者中的临床效果及对凝血因子的影响。方法 取2016年5月-2017年3月淄博市妇幼保健院收治的胎盘前置合并产后出血孕产妇60例,随机数字法分为对照组30例和观察组30例。对照组采用宫缩素治疗,观察组采用卡前列素氨丁三醇治疗。采用CA7000全自动血液分析仪测定患者手术前、后纤维蛋白原（FIB）、凝血活酶时间（APTT）、凝血酶原时间（PT）及血小板计数水平,比较2组临床疗效及凝血指标。结果 观察组治疗临床有效率为96.67%与对照组93.33%比较差异无统计学意义;观察组产后2 h、24 h出血量及产后24 h血红蛋白,均少于对照组（P〈0.05）;2组治疗前凝血因子水平比较差异无统计学意义;观察组治疗后血小板计数、PT、APTT水平,均低于对照组（P〈0.05）;观察组治疗后FIB水平,高于对照组（P〈0.05）;观察组治疗后不良反应发生率为6.67%与对照组10.00%比较差异无统计学意义。结论 胎盘前置合并产后出血产妇娩出后采用卡前列素氨丁三醇治疗效果理想,有助于减少产后出血量,改善患者凝血因子水平,值得推广应用。
Objective To investigate the clinical effect and the influence to coagulation factor of carboprost tromethamine on the treatment of the patients with postpartum hemorrhage. Methods 60 pregnant women with placenta previa complicated with postpartum hemorrhage from May 2016 to March 2017 were randomly divided into the control group （n=30） and the observation group （n=30）. The control group were given oxytocin, the observation group were received carboprost tromethamine. Fibrinogen （FIB）, prothrombin time （APTT）, prothrombin time （PT） and platelet count before and after surgery in the two groups were analyzed by CA7000 automatic blood analyzer. The effect and coagulation indexes in the two groups were compared. Results The clinical curative rate in the observation group was 96.67% and 93.33% in the control group, the differences had no statistically significant. The amount of hemorrhage in postpartum 2h and 24h and the hemoglobin in postpartum 24h in the observation group were less than those in the control group （P〈0.05）; There was no significant difference about coagulation indexes between the 2 groups before treatment;The platelet count, PT and APTT levels in the observation group were lower than those in the control group, and the level of FIB was higher than that in the control group （P〈0.05）; The incidence of adverse reaction was 6.67% in the observation group and 10% in the control group, the difference was not statistically significant. Conclusion Choosing carboprost tromethamine to treat placenta prevail complicated with postpartum hemorrhage has a good curative effect, which is helpful to reduce the amount of postpartum hemorrhage and improve the coagulation indexes, so it is worth popularizing
出处
《中国生化药物杂志》
CAS
2017年第8期267-269,共3页
Chinese Journal of Biochemical Pharmaceutics
