摘要
目的分析缩宫素联合米索前列醇预防产后出血的临床效果。方法选取宁波镇海第二医院妇产科2014年9月~2015年3月收治的分娩产妇共78例为观察对象,按随机、双盲原则分为观察组41例和对照组37例,对照组给予缩宫素进行产后出血的预防治疗,观察组给予缩宫素和米索前列醇联合治疗,对比2组产妇用药前后脉搏、舒张压、收缩压、不同时点出血量、用药后（hemoglobin,Hb）、红细胞比容（hematocrit,Hct）变化情况。结果观察组产妇用药后脉搏、舒张压、收缩压均明显优于对照组（P〈0.05）;观察组产妇在产后2 h出血量、产后24 h出血量均显著低于对照组（P〈0.05）;2组产妇产后Hb、Hct均有下降,但是观察组下降更明显,明显优于对照组（P〈0.05）。结论缩宫素联合米索前列醇可有效预防产后出血,显著降低产妇的出血量,无明显不良反应。
Objective To analyze clinical effect of misoprostol combined with oxytocin inprevention of postpartum hemorrhage. Methods 78 cases of maternal childbirth were observed from September 2014-March 2015,according to a randomized,double-blind principle divided into observation group（ n = 41 cases） and control group（ n = 37 cases）. Control group were given oxytocin to prevention of postpartum hemorrhage,observation group were given oxytocin and misoprostol combination therapy,compared pulse,diastolic blood pressure,systolic blood pressure,the amount of bleeding at different time points pre-and post-treatment between two groups, compared hemoglobin（ Hb） and hematocrit（ Hct） changes post-treatment.Results The maternal pulse after treatment,diastolic blood pressure,systolic blood pressure of observation group were significantly better than that of control group（ P〈0. 05）; groups were observed at 2 h post-partum bleeding,postpartum hemorrhage 24 h were significantly lower than the control group（ P〈0. 05）; two postpartum Hb,Hct were decreased,but observation group decreased more significantly than control group（ P〈0. 05）.Conclusion Oxytocin combined with misoprostol could be effective in preventing postpartum hemorrhage,significantly reduce maternal bleeding,has no significant adverse effect.
出处
《中国生化药物杂志》
CAS
2016年第3期37-39,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
浙江省医药卫生一般研究计划(2014KYB139)
关键词
缩宫素
米索前列醇
产后出血
出血量
oxytocin
misoprostol
postpartum hemorrhage
blood loss
