摘要
目的观察针刺联合脑血疏口服液治疗瘀血阻络型血管性痴呆的临床疗效。方法将135例瘀血阻络型血管性痴呆患者随机分为基础组、药物组和针药组,每组45例。基础组进行常规的基础治疗,药物组在基础组治疗基础上给予脑血疏口服液进行治疗,针药组在基础组治疗基础上给予针刺联合脑血疏口服液进行治疗,疗程均为60 d。比较各组治疗前后简易精神状态量表(MMSE)、痴呆简易筛查量表(BSSD)和血管性痴呆中医辨证量表瘀血阻络型分表(简称SDSVDA)的评分;观察血浆降钙素基因相关肽(CGRP)、过氧化脂质(LPO)和血清尿酸(SUA)的变化。结果基础组脱落1例。各组治疗60 d后,针药组总有效率为91.1%(41/45),显著高于基础组的65.9%(29/44,P<0.01)和药物组75.6%(34/45,P<0.05);针药组MMSE、BSSD和SDSVDA评分较基础组和药物组改善更为显著(P<0.05);针药组CGRP、LPO和SUA水平的改善优于基础组和药物组(P<0.05)。结论传统针刺手法联合脑血疏口服液治疗瘀血阻络型血管性痴呆疗效显著。
Objective To observe the clinical efficacy of acupuncture plus Nao Xue Shu oral liquid in treating vascular dementia（VD） due to blood stasis blocking collaterals. Method A total of 135 patients with VD due to blood stasis blocking collaterals were randomized into a basic group, a medication group, and an acupuncture-medication group, 45 cases in each group. The basic group was intervened by conventional treatment, while the control group was additionally given Nao Xue Shu oral liquid, and the acupuncture-medication group was additionally intervened by acupuncture plus Nao Xue Shu oral liquid, 60 d as a treatment course. The Mini-mental State Examination（MMSE）, Brief Screening Scale for Dementia（BSSD） and the syndrome of blood stasis blocking collaterals subscale in the syndrome differentiation scale of vascular dementia（SDSVDA） were scored before and after the treatment, and the changes of calcitonin gene-related peptide（CGRP）, lipid peroxidation（LPO） and serum uric acid（SUA） were also observed. Result One case dropped out in the basic group. After 60-day treatment, the total effective rate was 91.1%（41/45） in the acupuncture-medication group, significantly higher than 65.9%（29/44） in the basic group（P〈0.01） and 75.6%（34/45） in the medication group（P〈0.05）. The improvements of MMSE, BSSD and SDSVDA scores in the acupuncture-medication group were more significant than those in the basic group and medication group（P〈0.05）. The improvements of CGRP, LPO and SUA levels in the acupuncture-medication group were superior to those in the basic group and medication group（P〈0.05）. Conclusion Traditional acupuncture method plus Nao Xue Shu oral liquid can produce a significant efficacy in treating VD due to blood stasis blocking collaterals.
出处
《上海针灸杂志》
2017年第8期918-922,共5页
Shanghai Journal of Acupuncture and Moxibustion
关键词
针刺
瘀血阻络
痴呆
血管性
针药并用
MMSE
BSSD
SDSVDA
Acupuncture
Blood stasis blocking collaterals
Dementia
Vascular
Acupuncture medication combined
MMSE
BSSD
SDSVDA
