摘要
胃癌的发病率和死亡率居于世界范围的前五位,而胃癌的特异性靶点较少.RhoA在胃癌中高表达,和肿瘤的侵袭和转移能力密切相关.越来越多的证据表明RhoA有望成为胃癌的肿瘤治疗靶点,能够预测肿瘤细胞的侵袭和转移能力.现将RhoA在肿瘤的作用机制及在胃癌中的最新研究进展进行综述.
The morbidity and mortality of gastric cancer is high all over the world, while less specific target of gastric cancer has been found. RhoA is highly expressed in gastric cancer, which is closely related to tumor invasion and metastasis. An increasing evidence has showed that RhoA is a potential target for gene therapy of gastric cancer, and it can predict the invasion and metastasis of tumor cells. This paper reviews the mechanism of RhoA and research progress in gastric cancer.
出处
《肿瘤研究与临床》
CAS
2017年第7期494-498,共5页
Cancer Research and Clinic
关键词
胃肿瘤
RHO相关激酶类
侵袭
转移
Gastric neoplasms
Rho-associated kinases
Invasion
Metastasis
