摘要
目的探讨高效抗反转录病毒治疗(HAART)联合冰火两重灸法,在治疗艾滋病病毒(HIV)感染者/AIDS病人(简称HIV/AIDS病人)时对肝功能的影响。方法选择62例HIV/AIDS病人,试验组和对照组各31例,观察两组的肝功能指标:丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)的变化。结果试验组(即HAART联合冰火两重灸组)和对照组(单纯HAART组)病例入组前在年龄和AST、ALT指标上差异均无统计学意义。试验组的病人治疗第3个月AST/ALT升高,其比例为22.58%,第6个月为38.71%,均低于对照组的54.84%及64.52%水平,两者差异有统计学意义(P<0.05);两组病人在起始HAART治疗后6个月均以AST指标升高为主,且在两组间差异有统计学意义(P<0.05),而在ALT指标上试验组低于对照组,但两组差异无统计学意义(P>0.05)。结论中医灸法可明显降低HAART药物引起肝损伤的发生率,但其作用机制有待进一步研究。
Objective To know the impact of moxibustion combined with HAART on liver function of AIDS patients.Methods A retrospective study was conducted based on the selected 62 AIDS patients,including 31 cases as an experimental group（HAART combined with moxibustion）and 31 cases as a control group（only HAART treatment）,to observe liver function change of the two groups with index of alanine amino transferase（ALT）,and aspartate amino transferase（AST）.Results The difference of the two groups in ages,and AST/ALT was not statistically significant.The incidence of AST/ALT elevations was 22.58%in the 3rd months and 38.71% in the 6th months,lower than 54.84% of the control group in the 3rd months and 64.52% in the 6th months（P0.05）,with the difference statistically significant.The patients of the two groups after 6months treatment were all increasing in AST,with obvious differences（P 0.05）,while ALT of the experimental group was lower than that of the control group,with the difference between the two groups not statistically significant（P0.05）.ConclusionHAART combined with moxibustion can obviously reduce the incidence of drug-induced liver injury.However,its mechanism needs further research.
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2017年第7期603-605,共3页
Chinese Journal of Aids & STD
基金
昆明市科技计划项目资助(2014-04-03-A-S-02-0008)
