摘要
目的探讨2型糖尿病(T2DM)患者血清结缔组织生长因子(CTGF)变化及其与糖尿病肾病的相关性。方法T2DM患者62例,根据尿白蛋白排泄量(UAER)分为正常蛋白尿组(A组,24例,UAER<30mg/d)、微量尿蛋白组(B组,20例,UAER 30~300mg/d)和糖尿病临床蛋白尿组(C组,18例,UAER>300mg/d)。另选择同期在我院进行体检的健康者20例为对照(D)组。采用ELISA法测定各组血清CTGF水平。结果A、B、C组UAER和CTGF均高于D组(P<0.05),且B、C组高于A组(P<0.05),C组亦高于B组(P<0.05)。T2DM患者血清CTGF水平与UAER呈正相关(rs=0.890,P<0.01)。结论 CTGF在糖尿病肾病的发生、发展中起重要作用,是预测糖尿病肾病的理想指标。
Objective To investigate the change of serum connective tissue growth factor（CTGF）in the patients with type 2 diabetes mellitus（T2DM）and its correlation with diabetic nephropathy（DN）.Methods A total of 62 patients with T2 DM was divided into three groups of A（UAER〈30 mg/d,24cases）,B（UAER 30-300 mg/d,20cases）and C（UAER〉300 mg/d,18cases）.Twenty healthy subjects were selected as the controls（group D）.Serum CTGF levels were measured by ELISA.Results Serum levels of UAER and CTGF in groups of A,B and C were higher than those in group D（P〈0.05）,which were higher in groups of B and C than those in group A（P〈0.05）and were higher in group C than those in group B（P〈0.05）.Serum level of CTGF in T2 DM patients was positively correlated with that of UAER（rs =0.890,P〈0.01）.Conclusion Serum CTGF level plays an important role in the occurrence and development of DN and is an ideal indicator for predicting DN.
出处
《江苏医药》
CAS
2017年第13期943-945,共3页
Jiangsu Medical Journal
关键词
2型糖尿病
结缔组织生长因子
糖尿病肾病
Type 2 diabetic mellitus
Connective tissue growth factor
Diabetic nephropathy
